Stand-Off Sers Detection Using Nanoparticles

C.A. Batt, C. Bardliving, A. Phifer, P. Barahona
Cornell University, US

Keywords: sensors


Surface enhanced Raman scattering (SERS) represents a valuable spectral interrogation platform that combines a robust signal and an informative spectra. We have been developing a number of different nanoparticle-based SERS to small molecules. Gold or silver nanoparticles when coupled to an analyte specific binding agent can be used to detect a number of small molecules, including pesticides. The challenges are mainly in the area of target specificity and binding the target from a dilute aqueous pool. These challenges are being met by the design of the nanoparticles including the use of molecular imprinting and also incorporation of selective binding agents such as aptamers. Attention to the overall design is important as we look at the nanoparticles as just one component in the overall system.