The Spider Effect: a Novel Framework to Categorize Microglial Activation Status and Modulation

R.A. Jonas, T.F. Yuan, Y.X. Liang, J.B. Jonas, D.K.C. Tay, R.G. Ellis-Behnke
Massachusetts Institute of Technology, US

Keywords: microglia, CNS regeneration, brain repair, diagnostic


The Spider Effect is a novel framework that categorizes the activation status of microglia using morphological attributes. This quantitative system reduces the level of inflammation to a number, providing an objective measure of inflammation status in the CNS.