Colloidal Structures of Micro-and Nano- Drug Particles in Polymeric Networks

P. Takhistov, P. Huynh
Rutgers, the State University of New Jersey, US

Keywords: terapeutic films, drug, nanoparticles, controlled release, stability

Summary:

In the production of polymeric terapeutic films for the systemic delivery of active pharmaceutical ingredient (API), poorly soluble Class II API is dispersed and stabilized by surfactants, then surfactant-stabilized micro- or nano- API particulates are introduced to biocompatible polymers. However, in polymer blends, surfactants can be displaced by polymers, and this can impact the stability of API particle. To provide the structural information on API particulate distribution in biocompatible polymeric networks, we investigated model film formulation with griseofulvin, naproxen and fenofibrate particulates stabilized by different surfactants (anionic, cationic, and non-ionic) sodium dodecyl sulfate-SDS, cetylpyridinium chloride-CPC, and lecithin respectively) in HPMC. System was characterized by means of several techniques. Based on obtained data we propose a mechanistic model which allow to predict structural organization and aggregative stability of pharmaceutical ingredients within biopolymeric matrix.