Magnetic Nanoparticle Hyperthermia for Treatment of Bladder Cancer: A Large Animal Feasibility Study

A. Mashal, M. Huisjen, K. McNerny, K. Frantz, M. Susedik, C. Adams, A. Updegrave, M. Ross, J. Tondu, D. McKenna
Actium Biosystems, US

Keywords: magnetic nanoparticle, hyperthermia, cancer

Summary:

We propose a novel magnetic nanoparticle-mediated hyperthermia treatment for bladder cancer. In this approach, magnetic nanoparticles are mixed with the chemotherapy drug and instilled into the bladder via a catheter. The bladder is then illuminated with a magnetic field causing the nanoparticles to generate heat and increase the temperature of the bladder wall. A number of recent studies have shown that such combinations of intravesical chemotherapy and hyperthermia reduce the recurrence rates of non-muscle invasive bladder cancer when compared to chemotherapy alone. As a first step, we completed a round of large animal studies, using eight female pigs, to test the feasibility of achieving therapeutic temperatures in the bladder wall. In these studies, biocompatible magnetic nanoparticles were instilled into the pig bladder via a catheter and illuminated with biologically safe levels of magnetic fields using a custom made human-scale system. Our integrated system precisely controlled the temperature of the nanoparticle fluid to achieve therapeutic temperatures of 39 °C to 41 °C in the bladder interior wall for a duration of one hour. Necropsy and histology results showed that the nanoparticles and mild heat only caused mild to moderate irritation to the bladder tissue.