Nano-Therapeutics for Blocking Multiple Targets: New Age for Combination Cancer Treatments

Julia Y.  Ljubimova

Julia Y. Ljubimova

Professor of Neurosurgery and Biomedical Sciences & Director of Nanomedicine Research Center,

Cedars-Sinai Medical Center

Julia Y. Ljubimova, MD, PhD, is Director of the Drug Delivery and Nanomedicine in the Department of Neurosurgery at Cedars-Sinai.

Her main interests are in the differential cancer gene expression as a tool for finding novel/early markers of cancer growth and development and design of new nanomedicine drugs against these and other tumor targets. Her group has developed nanobioconjugates that selectively target brain and breast cancers that could have less dose-limiting toxicity than current therapies.

Dr. Ljubimova joined the faculty at Cedars-Sinai to direct studies combining basic cancer research to discover specific human tumor markers with translational research. One of the novel markers, the structural tumor vessel wall protein laminin-411, is currently in a clinical trial as a prognostic and diagnostic marker for human glial tumor progression. These discoveries led to the development of new technologies for drug delivery and engineering of a new class of anti-cancer nanomedicine drugs for inhibition of tumor-specific molecular targets. In 2006, her project, “Nanotechnology for drug delivery and nanomedicine drug engeeneering to treat tumors”, was awarded a five-year NIH R01 grant. In 2010, several novel nanomedicine drugs developed in Dr. Ljubimova’s laboratory, to treat breast and brain tumors, were awarded a new NIH/R01 and NIH/U01 grant for five years each.

Dr. Ljubimova is also studying the influence of air pollution on brain molecular markers activation leading to differential expression of genes that play an important role in tumorigenesis. Her studies have been published in numerous peer-reviewed journals, including Cancer Research, the American Journal of Pathology, Angiogenesis, Nanomedicine (Lond) and PNAS. Her research is funded by three NIH grants as well as state and private funds.

Dr. Ljubimova earned her degrees from Kiev’s University in Ukraine and the Ukraine Academy of Sciences. She completed her postdoctoral training at the Baylor College of Medicine and University of California, San Diego.

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