Functionalized Self-Assembling Peptides for Immediate Hemostasis and Accelerative Liver Tissue Regeneration

T.Y. Cheng, H.C. Wu, W.H. Chang, M.Y. Huang, C.H. Lee, T.W. Wang
Department of Materials Science and Engineering, National Tsing Hua University, TW

Keywords: nanomaterial, functionalized, hydrogel, hemostasis, tissue regeneration

Summary:

Traumatic injury or surgery may trigger extensive bleeding. However, conventional hemostatic methods have limited efficacy and may cause surrounding tissue damage. In this study, we use self-assembling peptides (SAPs) and specifically extend fragments of functional motifs derived from fibronectin and laminin to evaluate the capability of these functionalized SAPs in the effect of hemostasis and liver tissue regeneration. From the results, these peptides could self-assemble into nanofibrous network structure and became gelation into hydrogel with pH adjustment. In animal study, the efficacy of hemostasis was achieved immediately within seconds in rat liver model. The histological analyses by H/E stain and immunohistochemistry revealed that SAPs with these functionalized motifs significantly enhanced liver tissue regeneration. In brief, these SAPs may have potential as pharmacological tools to extensively advance clinical therapeutic applications in hemostasis and tissue regeneration in the field of regenerative medicine.