VEGF-dependent mechanism of anti-angiogenic action of diamond nanoparticles in glioblastoma multiforme tumor.

M. Grodzik, E. Sawosz, M. Wierzbicki, A. Hotowy, M. Prasek, S. Jaworski, A. Chwalibog
Warsaw University of Life Sciences, PL

Keywords: diamond nanoparticle, glioma, brain cancer, angiogenesis

Summary:

Inhibition of tumor angiogenesis suppresses tumor growth and prevents metastasis, and is a key target in cancer therapy. Novel materials, nanoparticles of carbon allotropes (C60 fullerenes, graphite nanoparticles, multi-walled carbon nanotubes, single-walled carbon nanotubes and diamond nanoparticles) have antiangiogenic potential. However, their mechanism of action is unclear. We hypothesize that diamond nanoparticles can bind VEGF or their receptors and this way influence signal transduction between cells. Our research shows, that diamond nanoparticles has affinity to VEGF-A protein.