Solid-state electronics and single-molecule biophysics

K. Shepard
Columbia University, US

Keywords: graphene, CNT

Summary:

Technological advances in the development of fluorescent probes, solid-state imagers, and microscopy techniques have enabled biomolecular studies at the single-molecular level. Fluorescent techniques use light as an intermediary and rely on imagers for interfacing to the solid-state. More intriguing are new electronic techniques for single-molecule detection based on charge. In particular, both nanopores and nanotube field-effect transistors have demonstrated capabilities for single-molecule detection. Here, we review and discuss the potential advantages these direct solid-state interfaces bring to biophysics in terms of transducer gain, signal-to-noise ratio, specificity and spatial resolution. Integration with CMOS electronics is key to realizing many of these advantages.