A Metallofullerene Nanoparticle Platform for Imaging and Treatment of Glioblastoma Multiforme Tumors

H.C. Dorn, J. Zhang, P. Fatouros, M.D. Shultz, J.D. Wilson
Virginia Polytechnic Institute and State University, US

Keywords: nanoparticle, tumor imaging

Summary:

Glioblastoma multiforme (GBM) brain tumors occur as masses with infiltrative margins that are extremely invasive. GBMs result in a high recurrence rate with a poor prognosis for patients who are newly diagnosed with only an ~14 month median survival rate. During the last few years, we have focused on the development of a trimetallic nitride templated endohedral metallofullerenes (TNT EMFs) nanoparticle platform for magnetic resonance (MR) imaging,1-3 brain tumor brachytherapy3 and targeting.4-5 One of the major goals of this work has been the preparation of a number of different radionuclides (177Lu) both encapsulated within the fullerene cage and/or attached via external ligands.3-5 Our recent results and strategies for imaging, targeting, and treatment of GBM tumors will be the focus of this presentation.