Nanotech 2011

Cancer Nanotechnology

Cancer Nanotechnology

Symposium Chairs

Mansoor M. AmijiMansoor M. Amiji
Distinguished Professor and Chair, Department of Pharmaceutical Sciences
Northeastern University
Vladimir TorchilinVladimir Torchilin
Distinguished Professor and Director, Center for Pharmaceutical Sciences
Northeastern University

Confirmed Invited Speakers

Sangeeta N.  BhatiaNanosystems for RNAi in Cancer
Sangeeta N. Bhatia
Professor of Health Sciences and Technology and Professor of Electrical Engineering and Computer Science, Massachusetts Institute of Technology
Mark GrinstaffPolymeric Nanostructures for Cancer Therapy
Mark Grinstaff
Professor, Boston University
 Nanotechnology for Early Cancer Diagnosi
Michael Cima
Professor, MIT
Piotr  GrodzinskiNCI’s Alliance for Nanotechnology in Cancer – Lessons Learned and Plans for Phase 2
Piotr Grodzinski
Director of Nanotechnology for Cancer, NCI’s Alliance for Nanotechnology in Cancer
Scott EliasofNanotechnology Platforms for Cancer Therapy: from Bench to Bedside
Scott Eliasof
Senior Director, Research, Cerulean Pharmaceuticals
Darrell IrvineInterbilayer-crosslinked multilamellar vesicles: Engineering lipid vesicle nanostructure for enhanced drug and vaccine delivery
Darrell Irvine
Associate Professor of Materials Science and Engineering & Biological Engineering, Massachusetts Institute of Technology
Omid FarokhzadTargeted Polymeric Nanoparticles
Omid Farokhzad
Associate Professor, Department of Anesthesia, Harvard Medical School; Director, Laboratory of Nanomedicine and Biomaterials, Anaesthesia, Brigham And Women's Hospital
Anirban  MaitraNovel Nano-Therapies for Pancreatic Cancer
Anirban Maitra
Professor of Pathology and Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine
S. Nahum  GoldbergInterventional Oncology and Nanotechnology
S. Nahum Goldberg
Director, Minimally Invasive Tumor Therapy Laboratory, Beth Israel Deaconess Medical Center
Vladimir TorchilinCancer Nanotechnology: Path to the Clinic
Vladimir Torchilin
Distinguished Professor and Director, Center for Pharmaceutical Sciences
Northeastern University

Symposium Sessions

Tuesday June 14

10:30 TechConnect Corporate Partnering: Pharma & Biotech
4:00 Italian Trade Commission Reception - Nanotech booth 1607, Cleantech booth 707
4:00 Innovation Showcase & Poster Session - Reception (4:00 - 6:00)
 Cancer Nanotechnology

Wednesday June 15

8:30 Cancer Nanotechnology 1
10:30 Cancer Nanotechnology 2
1:30 Cancer Nanotechnology 3
3:00 TechConnect IP Partnering: Pharmaceuticals
4:00 Piemonte Agency For Investments, Export And Tourism Reception - Nanotech booth 1607, Cleantech booth 707
4:00 Innovation Showcase & Poster Session - Reception (4:00 - 6:00)

Thursday June 16

10:30 Biosensors: General Applications
3:30 Cancer Nanotechnology 4

Symposium Program

Tuesday June 14

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10:30TechConnect Corporate Partnering: Pharma & BiotechRoom 309
Session chair: Didier Leconte, MSBi Valorisation, CA
10:30Merck TechConnect Partnering
R. Leonard, Merck, US
10:50Novartis TechConnect Partnering
B. Thorner, Novartis, US
11:30Sanofi Aventis TechConnect Partnering
S. Natesan, Sanofi Aventis, US
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4:00Italian Trade Commission Reception - Nanotech booth 1607, Cleantech booth 707Expo Hall
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4:00Innovation Showcase & Poster Session - Reception (4:00 - 6:00)Expo Hall
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Cancer NanotechnologyExpo Hall
-Polymersomes and Imaging: An Quantitative Approach
A.S. Joseph, N.J. Brown, G. Battaglia, University of Sheffield, UK
-Biocompatible nanophosphors as biomarkers for cancer detection
G.A. Sotiriou, D. Franco, A. Ferrari, D. Poulikakos, S.E. Pratsinis, Particle Technology Laboratory, ETH Zurich, CH
-Investigating the role of the FOXA1 protein in cancer with Scanning Probe Microscopy
I. Theodorou, Imperial College London, UK
-Improve the photodynamic detection and therapy of cancers with gold nanorods
J-Y Chen, Fudan university, Shanghai, China, CN
-Enhanced Cell Electro-permeabilisation Combined with Phototherapy to Target-Killing Cancer Cells by Using Multi Functional Carbon Nanotubes
P-C Lee, National Taiwan University, TW
-Ultra-Small Gold-Doxorubicin Rapidly Kill Cancer Cells
X. Zhang, J.L. Nadeau, H. Chibli, McGill University, CA
-Polymer-based delivery vehicle for cisplatin
D.B. Vieira, C.F.M. Menck, A.M. Carmona-Ribeiro, University of So Paulo, BR
-Prostate Cancer-Specific Drug Delivery and Imaging System: Design, Synthesis, and Characterization of Multi-functional AuNPs
K-L Dao, Northeastern University, US
-The Effect of Anticancer Nanotherapy on Lewis Lung Carcinoma
V.E. Orel, A.D. Shevchenko, N.A. Nikolov, N.N. Dzyatkovskya, A.V. Romanov, A.Yu. Richalskiy, A.P. Burlaka, S.M. Lukin, V.N. Uvarov, I.B. Schepotin, National cancer institute, UA
-Application of Magnetic Nanoparticles in Cancer Treatment
M.D. Coskun, H.M. Kutlu, G. Guney, Anadolu University, TR
-Anti-Cancer Gold Nanoparticle Conjugates: Endocrine Targeted Treatment Strategies and Laser Photothermal Therapy
E.C. Dreaden, E.B. Dickerson, I.H. El-Sayed, X. Huang, J.F. McDonald, A.K. Oyelere, M.A. El-Sayed, Georgia Institute of Technology, US

Wednesday June 15

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8:30Cancer Nanotechnology 1Room 304
Session chair: Mansoor Amiji, Northeastern University, US
8:30Cancer Nanotechnology Opportunities and Challenges View from the NCI Alliance for Nanotechnology in Cancer (invited presentation)
P. Grodzinski, National Cancer Institute, US
9:15Cancer Nanotechnology: Path to the Clinic (invited presentation)
V. Torchilin, Northeastern University, US
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10:30Cancer Nanotechnology 2Room 304
Session chair: Mansoor Amiji, Northeastern University, US
10:30Nanotechnology for Early Cancer Diagnosics (invited presentation)
M. Cima, Massachusetts Institute of Technology, US
11:00Targeting Tumors by Nano-Engineering Immune Cells (invited presentation)
D. Irvine, Massachusetts Institute of Technology, US
11:30Microfluidic Platforms for Early Cancer Detection (invited presentation)
S. Stott, Massachusetts General Hospital, US
12:00Interventional Oncology and Nanotechnology (invited presentation)
S.N. Goldberg, Beth Israel Deaconess Medical Center, US
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1:30Cancer Nanotechnology 3Room 304
Session chair: Mansoor Amiji, Northeastern University, US
1:30Polymeric Nanostructures for Cancer Therapy (invited presentation)
M. Grinstaff, Boston University, US
2:00Targeted Polymeric Nanoparticles (invited presentation)
O. Farokhzad, Harvard Medical School, Brigham And Womens Hospital, US
2:30Nanosystems for RNAi in Cancer (invited presentation)
S.N. Bhatia, Massachusetts Institute of Technology, US
3:00Novel Nano-Therapies for Pancreatic Cancer (invited presentation)
A. Maitra, Johns Hopkins School of Medicine, US
3:30Nanotechnology Platforms for Cancer Therapy: from Bench to Bedside (invited presentation)
S. Eliasof, Cerulean Pharmaceuticals, US
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3:00TechConnect IP Partnering: PharmaceuticalsRoom 303
Session chair: Belen Martinez, CaramelTech, MX
3:00New Strategies For Secure, Non-Invasive Transitional for Brain Cancer Treatment
C. Michel, SOCPRA, CA
3:10Treatment of Influenza Virus-Mediated Lung Injury: Blocking the A1-Adenosine Receptor
I. Davis, The Ohio State University, US
3:20High-Throughput Label-Free Nanoparticle Detection And Size Assay
F. Caporale, University of California Santa Barbara, US
3:30Radionuclide-Loaded Liposome
C. Burke, UT Health Science Center at San Antonio, US
3:40Cerium oxide nanoparticles for treatment and prevention of Alzheimers disease, Parkinsons disease, and disorders associated with free radical production and/or mitochondrial dysfunction.
B. Rzigalinski, Virginia Coll. of Osteopathic Medicine, US
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4:00Piemonte Agency For Investments, Export And Tourism Reception - Nanotech booth 1607, Cleantech booth 707Expo Hall
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4:00Innovation Showcase & Poster Session - Reception (4:00 - 6:00)Expo Hall

Thursday June 16

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10:30Biosensors: General ApplicationsRoom 304
Session chair: Srinivas Iyer, Los Alamos National Labs, US
10:30From Rational Design to Probe Optimization: the Role of Nanoparticle Valency in Single Cancer Cell Detection in Blood via Magnetic Relaxation
C. Kaittanis, S. Santra, J.M. Perez, University of Central Florida, US
10:50Highly robust array of nanosensing platform for biosensing application
I. Stateikina, A. Ng, R. Chinnappan, H. liu, M. Ahmed, M. Zourob, INRS, CA
11:10Electrochemistry in nanopore/electrode structures - from pore fabrication to DNA sequencing-by-tunneling
T. Albrecht, Imperial College London, UK
11:30Bio-inspired Optoelectronic Digital Nose
M. Bayindir, A. Yildirim, M. Vural, M. Yaman, Bilkent University, TR
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3:30Cancer Nanotechnology 4Room 206
Session chair: Mansoor Amiji, Northeastern University, US
3:30New High Conductance DEP Devices for Detection of Cancer Related DNA Nanoparticulate Biomarkers and Nanoparticles in Whole Blood
M.J. Heller, A. Sonnenberg, University of California San Diego, US
3:50Label-free Raman Micro-Spectral Imaging of the Microenvironment of PANC-1 Spheroids
T. Chernenko, R. Shah, E. Zuser, M. Diem, M. Amiji, Northeastern University, US
4:10Microfluidic System for the High-Throughput Reproducible Synthesis of Therapeutic Polymeric Nanoparticles
P.M. Valencia, M. Rhee, R. Langer, O. Farokhzad, R. Karnik, Massachusetts Institute of Technology, US
4:30Plasmonic Nanobubbles as Tunable Theranostic Agents
E. Lukianova-Hleb, P. Constantinou, B. Danysh D.S. Wagner, R.A. Drezek, J.H. Hafner, M.C. Farach-Carson, D.D. Carson, D.O. Lapotko, Rice University, US
4:50Ratiometric Tumor Hypoxia Imaging Agents based on Dual-Emissive Difluoroboron beta-Diketonate-Poly(lactic acid) Materials
G. Zhang, G.M. Palmer, M.W. Dewhirst, C.L. Fraser, University of Virginia, US

Welcome

NSTI is proud to collaborate with the National Cancer Institute (NCI) in presenting a Special Symposium on Nanotechnology for Cancer Prevention, Diagnosis and Treatment.

Towards the end of eliminating suffering and death from cancer, the National Cancer Institute is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, image and treat cancer. The NCI-NSTI Nanotechnology for Cancer Special Symposium will run in parallel with the Nanotech 2010 and the BioNano 2010 providing a unique multidisciplinary environment directed towards addressing the challenges of cancer research and treatment.

Video Journey Into Nanotechnology

Watch Video Journey Into Nanotechnology (provided courtesy of NCI)

Synopsis

Nanotechnology has the potential to have a revolutionary impact on cancer diagnosis and therapy. It is universally accepted that early detection of cancer is essential even before anatomic anomalies are visible. A major challenge in cancer diagnosis in the 21st century is to be able to determine the exact relationship between cancer biomarkers and the clinical pathology, as well as, to be able to non-invasively detect tumors at an early stage for maximum therapeutic benefit. For breast cancer, for instance, the goal of molecular imaging is to be able to accurately diagnose when the tumor mass has approximately 100-1000 cells, as opposed to the current techniques like mammography, which require more than a million cells for accurate clinical diagnosis.

In cancer therapy, targeting and localized delivery are the key challenges. To wage an effective war against cancer, we have to have the ability to selectively attack the cancer cells, while saving the normal tissue from excessive burdens of drug toxicity. However, because many anticancer drugs are designed to simply kill cancer cells, often in a semi-specific fashion, the distribution of anticancer drugs in healthy organs or tissues is especially undesirable due to the potential for severe side effects. Consequently, systemic application of these drugs often causes severe side effects in other tissues (e.g. bone marrow suppression, cardiomyopathy, neurotoxicity), which greatly limits the maximal allowable dose of the drug. In addition, rapid elimination and widespread distribution into non-targeted organs and tissues requires the administration of a drug in large quantities, which is often not economical and sometimes complicated due to non-specific toxicity. This vicious cycle of large doses and the concurrent toxicity is a major limitation of current cancer therapy. In many instances, it has been observed that the patient succumbs to the ill effects of the drug toxicity far earlier than the tumor burden.

This symposium will address the potential ways in which nanotechnology can address these challenges. Distinguished speakers will summarize the current state of the art and future barriers. Contributions are also solicited in the following topics.

  • Science and technologies for cancer diagnostic and imaging techniques using nanoparticles as reporter platforms and contrast enhancing agents;
  • Bionalaytical nanotechnology for detection of biomarkers
  • Nanoparticle platforms polymeric nanoparticles, lipid nanoparticles, metal nanoparticles, magnetic nanoparticles, and self-assembling nanosystems;
  • Synthetic chemistry required to design and optimize new strategies for nanoparticle preparation and functionalization;
  • Therapeutic targeted and intra-cellular drug and gene delivery using nanocarriers;
  • Nanoparticles for delivery of electromagnetic energy for hyperthermia and thermal ablation of tumors;
  • Theoretical modeling of nanoparticle processes in biological and medical environments, and of drug and gene delivery;
  • Combination therapies (drug and energy delivery) using nanoparticles
  • Clinical diagnosis and therapy of prostate, breast, and liver cancer.

Topics & Application Areas

  • Cancer Diagnostics
  • Cancer Biomarkers
  • Cancer Immunotherapeutics
  • Cancer Ligands
  • Drug Delivery
  • Other

Journal Submissions

Nanomedicine Journal

Nanomedicine: Nanotechnology, Biology and Medicine (Nanomedicine)

Nanomedicine: Nanotechnology, Biology and Medicine (Nanomedicine) is a newly established, international, peer-reviewed journal published quarterly. Nanomedicine publishes basic, clinical, and engineering research in the innovative field of nanomedicine. Article categories include basic nanomedicine, diagnostic nanomedicine, experimental nanomedicine, clinical nanomedicine, and engineering nanomedicine, pharmacological nanomedicine.

For consideration into the Nanomedicine: Nanotechnology, Biology and Medicine journal please select the “Submit to Nanomedicine: Nanotechnology, Biology and Medicine” button during the on-line submission procedure.

Nanoparticle Research

Journal of Nanoparticle Research

Selected Nanotech Proceedings papers will be reviewed and invited into a Special Issue of Journal of Nanoparticle Research. The journal disseminates knowledge of the physical, chemical and biological phenomena and processes in nanoscale structures.

For consideration into this Special Issue of Journal of Nanoparticle Research, please select the “Submit to Journal of Nanoparticle Research” button during the on-line submission procedure.

 

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