Polymeric Nanostructures for Cancer Therapy
My group pursues highly interdisciplinary research in the areas of biomedical engineering and macromolecular chemistry. The major goal in these research projects is to elucidate the underlying fundamental chemistry and engineering principles and to use that insight to direct our creative and scientific efforts. In one of our current research projects, we are designing, synthesizing, and characterizing novel dendrimers, termed ?biodendrimers,? for tissue engineering and biotechnological applications. Currently, we are evaluating these novel biomaterials for the repair of corneal lacerations, for the delivery of anti-cancer drugs, for the delivery of DNA, and as temporary biodegradable scaffolds for cartilage repair. In a second project, we are creating novel polymeric coatings termed ?interfacial biomaterials? that control biology on plastic, metal, and ceramic surfaces. In a third project, we are designing new polymeric films and nanoparticles loaded with anticancer drugs for the prevention of recurrent cancer after surgical resection.