Nanotech 2011

Cell adhesion behaviors on polyethylene terephthalate surface modified by surface-wave plasma-initiated graft polymerization

A. Nina, T. Ishizaki, N. Saito
National Institute of Advanced Industrial Science and Technology (AIST), JP

Keywords: surface-wave plasma, Poly(ethylene terephthalate), surface modification, cell culture


For better performance in biomedical applications, the PET surface still needs to be improved by functionalization, particularly controlling the hydrophilicity. In order to impart hydrophilicity to the PET surface, we tried to introduce acrylic acid (AA) monomer to the PET surface through a surface-wave plasma (SWP) process. As a result, we successfully produced stable hydrophilicity on the PET surface through plasma-initiated graft polymerization using the SWP process. The water contact angles of the PET surface modified with hydrophilic AA monomer decreased from approximately 80° before treatment to less than 35°. The hydrophilicity of the PET surface modified with hydrophilic AA monomer was maintained for 70 h. 3T3 fibroblast cells were cultured on the modified PET surface. After the cells were cultured for 48 h, on the untreated surface, the number of cultured cells was higher than the initial number of seeded cells. In contrast, the number of cells cultured on AA-modified surface was much lower than the initial number of seeded cells. We believe that our surface modification method would provide a way to control hydrophilicity and bioactivity of various polymer surfaces.

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