Nanotech 2011

siRNA Delivery Using Biodegradable Nanoparticles for Breast Cancer Therapy

S. Abbasi, P. Arghya, K. Afshan, S. Prakash
McGill University, CA

Keywords: nanoparticles, biodegradable, siRNA, breast cancer


Polyethylenimine (PEI)-coated human serum albumin (HSA) nanoparticles form suitable biocompatible carriers for therapeutic molecules. Small interfering RNA (siRNA) molecules have suggested great promise as a future therapy for breast cancer. In order to overcome the problems of degradation and low cellular transfection associated with siRNA, PEI-HSA nanoparticles are used. These nanoparticles are characterized to allow efficient delivery of siRNA to MCF-7 breast cancer cells.

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