Nanotech 2011

Indium Phosphide : Cadmium Free Quantum Dots for Cancer Imaging and Therapy

H. Chibli, L. Carlini, S. Park, N. Dimitrijevic, J.L. Nadeau
McGill University, CA

Keywords: InP, reactive oxygen species, cancer imaging, toxicity


We synthesised Indium phosphide (InP) quantum dots (QDs) with different shell layer. We demonstrate highly fluorescent labeling of cell lines after nonspecific endocytosis of the QD. With spin-trap electron paramagnetic resonance (EPR) spectroscopy and reporter assays we determined the nature of reactive oxygen species generated. The sulforodhamine B (SRB) viability assay indicates very low cytotoxicity in all cell line tested. These data indicate that straightforward methods of synthesis and solubilization result in InP QDs that are a viable alternative to cadmium-containing particles for biological applications.

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