Nanotech 2011

Anti-Cancer Gold Nanoparticle Conjugates: Endocrine Targeted Treatment Strategies and Laser Photothermal Therapy

E.C. Dreaden, E.B. Dickerson, I.H. El-Sayed, X. Huang, J.F. McDonald, A.K. Oyelere, M.A. El-Sayed
Georgia Institute of Technology, US

Keywords: gold, estrogen receptor, androgen receptor, breast cancer, prostate cancer, nanorod, photothermal therapy, laser, endocrine, nanoparticle, plasmon

Abstract:

Herein, we present recent progress by our laboratory exploring preclinical applications of gold nanoparticles as multifunctional agents for targeted anti-cancer drug delivery and laser photothermal therapy. Specifically, we will discuss the use of small-molecule hormone receptor antagonists as combined targeting/therapeutic agents for breast and prostate cancer treatment, as well as results from the first in vivo study demonstrating the efficacy of near-infrared laser photothermal cancer therapy using plasmonic gold nanorods. In the former, we show that the anti-estrogen tamoxifen and the anti-androgen nilutamide can be used to selectively target and deliver gold nanoparticles to hormone receptor-positive breast and prostate cancer cells, respectively, both with >10^4 fold enhanced potency over their respective free drugs. In both cases, uptake was observed to occur in a receptor-dependent fashion, presenting opportunities for the co-delivery of other chemotherapeutics, adjunctive laser photothermal therapy, and/or high-z enhanced radiation therapy. In the latter, we demonstrate the feasibility of in vivo near-infrared laser photothermal therapy using passive targeting of PEGylated gold nanorods. Tumor growth inhibition was observed following both iv and direct administration of the nanoconjugates and a single 10 min laser exposure. Resorption of >57% of the directly-injected tumors and 25% of the intravenously-treated tumors was shown over a 13-day period.
 

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