Nanotech 2011

Micronization of Active Pharmaceutical Ingredients (API) – from R&D to the production scale

S. Mende
NETZSCH Premier Technologies, US

Keywords: micronization, nanotechnology, comminution, dispersion, API

Abstract:

The comminution or desagglomeration of active pharmaceutical ingredients (API) is called micronization and brings about several advantages. The increase of the particle surface caused by the comminution results in a considerably better dissolution rate and bioavailability of the agents and therefore the APIs act faster. Due to the increased bioavailability a lower amount of APIs is required which in turn leads to a more cost-efficient product with less risks and side effects for the patient. Median particle particle sizes in the range of 100 nanometers can be acheived with this technology.
 

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