Bio Nanotech 2010 Nanotech 2010

2010 Symposium on

Nanotechnology for Cancer Prevention, Diagnosis and Treatment

CancerNano 2010

Cancer Diagnostics, Imaging & Treatment

June 20 - 24, 2010
Anaheim Convention Center
Anaheim, California, U.S.A

Symposium sponsors

National Cancer Institute National Institutes of Health

Symposium Co-Chairs

Mansoor Amiji Mansoor Amiji
Department of Pharmaceutical Sciences,
Northeastern University
Vladimir Torchilin Vladimir Torchilin
Bouvé College of Health Sciences,
Northeastern University

Invited Speaker

Jeff Hrkach Jeff Hrkach
Vice President, Pharmaceutical Sciences, BIND Biosciences
Shan X. Wang Shan X. Wang
Professor, Center for Magnetic Nanotechnology,
Stanford University

Joseph Irudayaraj Joseph Irudayaraj
Professor of Biological Engineering, Purdue University
Peter S. Conti Peter S. Conti
Professor, Biomedical Engineering, Radiology, Pharmacy, University Southern California
Samira Guccione Samira Guccione
Assistant Professor, Radiology, Stanford University
Jim Heaths Jim Heath
Gilloon Professor and Professor of Chemistry, Caltech
Jeffrey Zink Jeffrey Zink
Professor of Chemistry, UCLA
   

Symposium Sessions

Tuesday June 22

10:30 Cancer Nanotech
3:30 TechConnect Corporate Partnering
3:30 US-Korea TechConnect
4:00 Poster Session and TechConnect Expo (4:00 - 6:00)

Wednesday June 23

10:00 Networking Coffee Break
10:30 Cancer Nanotechnology
1:30 Cancer Nanotechnology
3:00 Cancer Nanotechnology
4:00 Poster Session and TechConnect Expo Reception (4:00 - 6:00) - Expo Hall
 Cancer Nanotechnology
6:00 TechConnect Innovation Showcase Reception (6:00 - 8:00) - Ballroom 3rd Floor

Thursday June 24

8:30 Keynotes: Transformational Nanotech
10:00 TechConnect Innovation Showcase Coffee Break - Ballroom 3rd Floor
10:30 Cancer Nanotechnologies
1:30 TechConnect Ventures: Biotech & Pharma
3:30 Novel Nanoparticle Approaches for Drug and Gene Delivery
5:00 TechConnect Investment Networking Reception - Second Floor

Symposium Program

Tuesday June 22

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10:30Cancer NanotechRoom 201 B
Session chair: Belén Martínez López, Perteneciente a la Universidad Panamericana
10:30Novel internalizing immunoliposome targeting epithelioid and sarcomatoid subtypes of mesothelioma cancer cells
A.K. Iyer, X. Zhu, J. Feng, X. Lan, Y. Su, Y. Liu, C.V. Broaddus, H.F. VanBrocklin, B. Liu, J. He, University of California San Francisco, US
10:50Targeting tumor associated macrophages using clodronate-loaded PLGA nanoparticles
G. Sharma, P. Karmali, M. Ramirez, Hui Xie, E. Ruoslahti, J. Smith, Burnham Institute for Medical Research, US
11:10Doxorubicin-loaded and Antibody-Conjugated Liposome-QD Hybrid Vesicles for Targeted Cancer Therapy and Imaging
B.W. Tian, W.T. Al-Jamal, M. Stuartb, K. Kostarelos, The School of Pharmacy, University of London, UK
11:30Polypeptide-based degradable plasmonic nanomatrices for combined photothermal ablation and chemotherapy of cancer cells
H-C Huang, Y. Yang, P. Koria, K. Rege, Arizona State University, US
11:50Nanomaterials Employed in Effective Tumor Treatment
X-J. Liang, National Center for Nanoscience and Technology of China, CN
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3:30TechConnect Corporate PartneringRoom 207 D
Session chair: Marjan Kraak, ETH Zurich, CH
3:30P&G TechConnect Partnering
S. Meller, Procter & Gamble, US
3:50Medtronic TechConnect Partnering
G. Muramoto, Medtronic, US
4:10Merck TechConnect Partnering
Y. Weiss, Merck, US
4:30GE Healthcare TechConnect Partnering
J. DeForrest, GE Healthcare, US
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3:30US-Korea TechConnectRoom 206 A
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4:00Poster Session and TechConnect Expo (4:00 - 6:00)Expo Hall

Wednesday June 23

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10:00Networking Coffee BreakFoyer 2nd Floor
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10:30Cancer NanotechnologyRoom 201 AB
Session chair: Mansoor Amiji, Northeastern University, US
10:30Technologies & Systems Approaches Towards Interrogating the Paradoxical Relationship between Cancer and the Immune System
J. Heath, California Institute of Technology, US
11:15Magneto-Nano Chips for Cancer Diagnostics
S.X. Wang, Stanford University, US
11:45Multifunctional Gold nanosensors for targeting and delivery
J. Irudayaraj, Purdue University, US
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1:30Cancer NanotechnologyRoom 201 AB
Session chair: Mansoor Amiji, Northeastern University, US
1:30Ultrasound Enhanced Diagnosis and Therapy in Cancer
S. Guccione, Stanford University, US
2:00Nanosystems for Molecular Imaging in Cancer
P. Conti, University of Southern California, US
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3:00Cancer NanotechnologyRoom 201 AB
Session chair: Mansoor Amiji, Northeastern University, US
3:00Mesoporous Silica Nanoparticles for Imaging and Drug Delivery
J. Zink, University of California Los Angeles, US
3:30High-Precision Therapeutics through Medicinal Nanoengineering™
J. Hrkach, BIND Biosciences, US
4:00Cancer Nanomedicines for Delivery of Hard-to-Deliver Pharmaceuticals
V. Torchilin, Northeastern University, US
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4:00Poster Session and TechConnect Expo Reception (4:00 - 6:00) - Expo HallExpo Hall
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Cancer NanotechnologyExpo Hall
-Visualization of Thyroid Cancer Signs by Atomic Force Microscopy
I.V. Reshetov, V.I. Chissov, S.S. Sukharev, E.N. Slavnova, N.N. Volchenco, V.A. Bykov, P.A.Hertzen Moscow Research Oncological Institute, RU
-Chip-Based Diagnostics of Cancer. Simultaneous Quantitation of Six Biomarkers
T. Ryabykh, T. Osipova, Z. Sokolova, N. Paklin, N.N. Blokhin Cancer Research Center, RAMS, RU
-Influence of Mechano– and Magnetochemically Synthesized Magnetosensitive Nanocomplex and Spatially Inhomogeneous Electromagnetic Irradiation on Transplanted Animal Tumor
V.E. Orel, A.D. Shevchenko, A.V. Romanov, I.I. Dzyatkovska, M.O. Nikolov, Yu.G. Mel’nik, N.M. Dzyatkovska, I.B. Shchepotin, V.N. Uvarov, National Cancer Institute, UA
-Minimal-dose cancer chemotherapy: Anti-cancer drugs loaded nanodevices towards time, site, and organ-specific releases for development of personalized nanomedicine
R.A. Khan, S.J. Newati, V.M. Singh, S. Sachdeva, R. Sharma, Manav Rachna International University (MRIU), IN
-Anti-K-Ras siRNA to Treat Pancreatic Cancer
D.C. Julien, A. Giri, M. Papasani, G. Murdoch, P. Hrdlicka, R.A. Hill, University of Idaho, US
-Multifunctional Fe3O4/ZnO core-shell nanoparticles for photodynamic therapy
J.C. Beltran, M.S. Tomar, S.P. Singh, O. Perales, L. Rivera, S. Peña, University of Puerto Rico, Mayaguez, PR
-Nano-carriers for targeted drug delivery in cancer therapy
R. Kaushik, R. Patel, I. Kadiyala, R. Alargova, R. Shawgo, F. Berlioz-Seux, H. Li, U. Germann, M. Briggs, Vertex Pharmaceuticals Incorporated, US
-Multifunctional Magnetic Multi-Walled Carbon Nanotubes for Anti-Cancer Drug Delivery
A. Lu, Y.J Lai, J.P. Chen, Chang Gung University, TW
-Nuclear Uptake of Polymer-Lipid Nanoparticle in Multi Drug Resistant Breast Cancer Cells Via Caveolae Mediated Endocytosis and Macropinocytosis
P. Prasad, A. Shuhendler, M. Rauth, X.Y. Wu, University of Toronto, CA
-Multimodality therapy: Enhancement of melanoma cell death with combination of heat shock protein 90 inhibitor, 17-(Allylamino)-17-demethoxygeldanamycin (17-AAG), and gold nanoparticles in a noninvasive radiofrequency field
W.D. Kaluarachchi, S.A. Curley, M D Anderson cancer Center, US
-Zebrafish as a universal in vivo model for plasmonic nanoparticle medicine
E. Lukianova-Hleb, C. Santiago, D. Wagner, J. Hafner, D. Lapotko, Rice University, US
-Development of new thermo-ablation therapy using magnetic nanoparticles and device for alternating magnetic field
S. Hashimoto, T. Oda, K. Yamada, Y. Ohara, N. Ohkohchi, T. Kanamori, Y. Ikehata, I. Nagano, H. Yanagihara, M. Kishimoto, E. Kita, University of Tsukuba, JP
-Nonlabelled Nanocarbon for application of targeting Tumor Cells Causing Thermal Energy Ablation Using Short Cycle Microwave Energy as Primary Or Adjunctive Therapy
M. DeSantis, T. Dalessandro, J. Ferretti, R. Mashioff, W. Bowne, S. Sclafani, J. Sorrento, VA MED CTR, US
-Cellular Binding and Uptake of Aptamer-Targeted Delivery Systems
W.T. Al- Jamal, J. Van den Bossche, B. Tian, A. Nunes, C. Fabbro, M. Prato, A. Biancoc, K. Kostarelosa, The School of pharmacy, UK
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6:00TechConnect Innovation Showcase Reception (6:00 - 8:00) - Ballroom 3rd FloorBallroom BC

Thursday June 24

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8:30Keynotes: Transformational NanotechRoom 303 CD
Session chair: Clayton Teague, NNCO, US
8:30Nanotechnology: Path Toward Commercialization at GE
M. Butts, General Electric, US
9:00Getting the Memristor to Market
S. Williams, Hewlett Packard, US
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10:00TechConnect Innovation Showcase Coffee Break - Ballroom 3rd FloorBallroom BC
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10:30Cancer NanotechnologiesRoom 201 D
Session chair: Belén Martínez López, Perteneciente a la Universidad Panamericana, US
10:30Detection of Cancer Related DNA Nanoparticulate Biomarkers and Nanoparticles in Whole Blood
M.J. Heller, R. Krishnan, A. Sonnenberg, University of California San Diego, US
10:50Combining gene therapy and nanomedicine to enhance the therapeutic potential of T cells
Y. Choi, H. Torikai, D.Y. Lee, Z. Li, D. Lo, G. Qin, C.H. Tung, E. Tasciotti, R. Raphael, S.L. Biswal, S. Ang, D.A. Lee, K.C. Li, L.J.N. Cooper, M.D. Anderson Cancer Center, US
11:10Bioluminescent Model for the Quantification of Photothermal Ablative Breast Cancer Therapy Mediated by Near-Infrared Nanoparticles
L.G. Gutwein, A.K. Singh, M.A. Hahn, M.C. Rule, S.C. Brown, B. Moudgil, S.R. Grobmyer, University of Florida, US
11:30Thermotherapy using magnetic nanoparticles: increased median survival time following tumor recurrence in glioblastoma multiforme patients
A. Jordan, K. Maier-Hauff, H. Niehoff, F. Ulrich, MagForce Nanotechnologies AG, DE
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1:30TechConnect Ventures: Biotech & PharmaRoom 207 B
Session chair: Lynn Foster, BPT Pharmaceuticals, US
1:30Adjuvance Technologies, Inc
J. Gardner, Adjuvance Technologies, Inc., US
1:40FluimediX
T. Ussing, FluimediX, DK
1:50MITI Systems
B. Sul, MITI systems, KR
2:00BioMers Pte Ltd
M. Fathianathan, BioMers Pte Ltd, SG
2:10Curapel Ltd
S. France, University of Manchester/ Curapel Ltd, UK
2:20NanGenex Inc
G. Heltovics, NanGenex Inc., HU
2:30Bilcare Technologies Singapore Pte Ltd
A. Burden, Bilcare Technologies Singapore Pte Ltd, SG
2:40Diomics Corporation
J. Morhet, Diomics Corporation, US
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3:30Novel Nanoparticle Approaches for Drug and Gene DeliveryRoom 201 C
Session chair: Matt Laudon, NSTI, US
3:30Enhanced Cytotoxicity of Doxorubicin Conjugated to Ultrasmall Au Nanoparticles
E. Zhang, K. Ntumba, J. Nadeau, McGill University, CA
3:50Novel mesoporous silicon particles as an efficient sustained delivery system for antibiotics
I. Yazdi, C. Chiappini, B. Weiner, M. Ferrari, E. Tasciotti, The University of Texas Health Science Center at Houston, US
4:10Delivery of Camptothecin to Cancer Cells with Silica Nanoparticles
P. Botella, I. Abasolo, C. Muniesa, J. Ruiz, Y. Fernández, M. Quesada, A. Corma, S. Schwartz Jr., INSTITUTO DE TECNOLOGIA QUIMICA (UPV-CSIC), ES
4:30Enhanced cellular internalisation and gene silencing with a series of cationic dendron-multiwalled carbon nanotube:siRNA complexes
K.T. Al-Jamal, F.M. Toma, A. Yilmazer, H. Ali-Boucetta, A. Nunes, M.A. Herrero, B. Tian, A. Bianco, M. Prato, K. Kostarelos, The School of Pharmacy, UK
4:50Stem cell-directed theranostic nanovectors for cancer intervention
J.O. Martinez, F. Amaya, R. Serda, X. Liu, M. Ferrari, M.G. Kolonin, E. Tasciotti, The University of Texas Health Science Center - Houston, US
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5:00TechConnect Investment Networking Reception - Second FloorFoyer 2nd Floor

Welcome

NSTI is proud to collaborate with the National Cancer Institute (NCI) in presenting a Special Symposium on Nanotechnology for Cancer Prevention, Diagnosis and Treatment.

Towards the end of eliminating suffering and death from cancer, the National Cancer Institute is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, image and treat cancer. The NCI-NSTI Nanotechnology for Cancer Special Symposium will run in parallel with the Nanotech 2010 and the BioNano 2010 providing a unique multidisciplinary environment directed towards addressing the challenges of cancer research and treatment.

Video Journey Into Nanotechnology

Watch Video Journey Into Nanotechnology (provided courtesy of NCI)

Synopsis

Nanotechnology has the potential to have a revolutionary impact on cancer diagnosis and therapy. It is universally accepted that early detection of cancer is essential even before anatomic anomalies are visible. A major challenge in cancer diagnosis in the 21st century is to be able to determine the exact relationship between cancer biomarkers and the clinical pathology, as well as, to be able to non-invasively detect tumors at an early stage for maximum therapeutic benefit. For breast cancer, for instance, the goal of molecular imaging is to be able to accurately diagnose when the tumor mass has approximately 100-1000 cells, as opposed to the current techniques like mammography, which require more than a million cells for accurate clinical diagnosis.

In cancer therapy, targeting and localized delivery are the key challenges. To wage an effective war against cancer, we have to have the ability to selectively attack the cancer cells, while saving the normal tissue from excessive burdens of drug toxicity. However, because many anticancer drugs are designed to simply kill cancer cells, often in a semi-specific fashion, the distribution of anticancer drugs in healthy organs or tissues is especially undesirable due to the potential for severe side effects. Consequently, systemic application of these drugs often causes severe side effects in other tissues (e.g. bone marrow suppression, cardiomyopathy, neurotoxicity), which greatly limits the maximal allowable dose of the drug. In addition, rapid elimination and widespread distribution into non-targeted organs and tissues requires the administration of a drug in large quantities, which is often not economical and sometimes complicated due to non-specific toxicity. This vicious cycle of large doses and the concurrent toxicity is a major limitation of current cancer therapy. In many instances, it has been observed that the patient succumbs to the ill effects of the drug toxicity far earlier than the tumor burden.

This symposium will address the potential ways in which nanotechnology can address these challenges. Distinguished speakers will summarize the current state of the art and future barriers. Contributions are also solicited in the following topics.

Topics and Applications

  • Science and technologies for cancer diagnostic and imaging techniques using nanoparticles as reporter platforms and contrast enhancing agents;
  • Bionalaytical nanotechnology for detection of biomarkers
  • Nanoparticle platforms polymeric nanoparticles, lipid nanoparticles, metal nanoparticles, magnetic nanoparticles, and self-assembling nanosystems;
  • Synthetic chemistry required to design and optimize new strategies for nanoparticle preparation and functionalization;
  • Therapeutic targeted and intra-cellular drug and gene delivery using nanocarriers;
  • Nanoparticles for delivery of electromagnetic energy for hyperthermia and thermal ablation of tumors;
  • Theoretical modeling of nanoparticle processes in biological and medical environments, and of drug and gene delivery;
  • Combination therapies (drug and energy delivery) using nanoparticles
  • Clinical diagnosis and therapy of prostate, breast, and liver cancer.

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Journal Submissions

Nanomedicine Journal

Nanomedicine: Nanotechnology, Biology and Medicine (Nanomedicine)

Nanomedicine: Nanotechnology, Biology and Medicine (Nanomedicine) is a newly established, international, peer-reviewed journal published quarterly. Nanomedicine publishes basic, clinical, and engineering research in the innovative field of nanomedicine. Article categories include basic nanomedicine, diagnostic nanomedicine, experimental nanomedicine, clinical nanomedicine, and engineering nanomedicine, pharmacological nanomedicine.

For consideration into the Nanomedicine: Nanotechnology, Biology and Medicine journal please select the “Submit to Nanomedicine: Nanotechnology, Biology and Medicine” button during the on-line submission procedure.

Nanoparticle Research

Journal of Nanoparticle Research

Selected Nanotech Proceedings papers will be reviewed and invited into a Special Issue of Journal of Nanoparticle Research. The journal disseminates knowledge of the physical, chemical and biological phenomena and processes in nanoscale structures.

For consideration into this Special Issue of Journal of Nanoparticle Research, please select the “Submit to Journal of Nanoparticle Research” button during the on-line submission procedure.

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