Nanotech 2010

Combining gene therapy and nanomedicine to enhance the therapeutic potential of T cells

Y. Choi, H. Torikai, D.Y. Lee, Z. Li, D. Lo, G. Qin, C.H. Tung, E. Tasciotti, R. Raphael, S.L. Biswal, S. Ang, D.A. Lee, K.C. Li, L.J.N. Cooper
M.D. Anderson Cancer Center, US

Keywords: electroporation, indium, gold nanoparticle, T cell


we have developed a high throughput electroporator (HiTE) to manipulate large numbers (~10^9) of T cells ex vivo for clinical uses. HiTE is designed to electro-transfer RNA species to redirect T-cell specificity and gold nanoparticles (Au-NPs) that can be functionalized to enhance T-cell biology. By introducing both transgenes and Au-NPs we are generating T cells that can be rapidly modified to act as a drug-delivery system for targeted therapy of lung cancer.
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