Nanotech 2010

A proof of concept: a model of targeted stealth nanoparticles that are stable and biocompatible for RNA interference in vivo to macrophages

M.S. Yusuf, A.D. Miller, C.H. Prata
Imperial College Gene Therapies Centre, UK

Keywords: liposome, Mannose receptor, siRNA, Macrophage


Bringing together advances generated through the developing fields of bionanotechnology and gene therapy, and demonstrated through the ABCD model, we propose a biocompatible, stable, specific stealth lipoplex targeting macrophages, as proof of concept, which is to be developed into a novel disease modifying agent in the treatment of systemic autoimmune diseases such as rheumatoid arthritis
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