Nanotech 2010

Polymer nanoparticles as nanoformulation agents

H. Pham, F. Li, J.B. Goh, J. Dinglasan, D. Anderson
Vive Nano, Inc., CA

Keywords: polymer nanoparticles, polyelectrolytes, nanoformulation


An approach to produce polymer nanoparticles with tailored characteristics to accommodate different nanoformulation applications is presented. Polymer nanoparticles are made from the collapse of polyelectrolytes in the presence of counterions and/or different solvents. The size, hydrophobic/hydrophilic character, as well as surface interaction characteristics of collapsed polyelectrolyte nanoparticles can be controlled by varying the degree of crosslinks and the degree of chemical modification of the parent polyelectrolyte chain. Depending on the characteristics of the polymer nanoparticle (i.e. size, hydrophobic/hydrophilic character, degree of crosslinking, etc.) different molecules like dyes, pigments, agricultural and pharmacological active ingredients, and aromatics can be loaded into the polymer nanoparticles. Polymer nanoparticles made with this approach are typically smaller in size (10-50 nm) than those achievable using other methods. Data illustrating the different characteristics of the polymer nanoparticles such as hydrophobic/hydrophilic character, size, and the interactions of the polymer nanoparticles with different substrates will be presented.
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