Nanotech 2010

Development, in vitro and in vivo evaluation of long circulating liposomes of plumbagin in C57BL/6J mice bearing B16F1 melanoma

M.R. Sunil Kumar, B. Kiran Aithal, N. Udupa, B.S. Satish Rao
MANIPAL LIFE SCIECNES CENTRE, MANIPAL UNIVERSITY, IN

Keywords: plumbagin, liposomes, in vitro release, pharmacokinetics, B16F1 melanoma

Abstract:

Conventional and long circulating liposomes of plumbagin, an anticancer agent were prepared by thin film hydration method using soya lecithin (SPC), cholesterol and DSPE-PEG-2000. The prepared formulations were characterized in vitro in terms of size, zeta potential and drug loading. The conventional formulation F3b with 9:3 (SPC:Cholesterol) and 9:3:0.5 molar ratio (SPC:Cholesterol:DSPE-PEG2000) in long circulating liposomes C2 were taken up to further study pharmacokinetic and pharmacodynamics in C57BL/6J mice bearing B16F1 melanoma as tumor model. The present study is expected to overcome the shortcomings of plumbagin possessing short biological half-life by providing a safe and effective drug delivery system like long circulating liposomes to target specifically to tumor site through enhanced permeability and retention concept (EPR effect) at tumor site to improve therapeutic efficacy and reduced toxicity.
 
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