Nanotech 2010

Picomolar Sensitivity MRI and photoacoustic imaging of cobalt nanoparticles (invited presentation)

L-S. Bouchard, M. Sabieh Anwar, G.L. Liu, X. Wang, F.F. Chen
University of California, Los Angeles, US

Keywords: nanoparticles, MRI, imaging, cobalt


Multimodality imaging based on complementary detection principles has broad clinical applications and promises to improve the accuracy of medical diagnosis. This means that a tracer particle advantageously incorporates multiple functionalities into a single delivery vehicle. In the present work, we explore a unique combination of MRI and photoacoustic tomography (PAT) to detect picomolar concentrations of nanoparticles. The nanoconstruct consists of ferromagnetic (Co) particles coated with gold (Au) for biocompatibility, and a unique shape that enables optical absorption over a broad range of frequencies. The end result is a dual-modality probe useful for the detection of trace amounts of nanoparticles in biological tissues, whereby MRI provides volume detection while PAT performs edge detection.
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