Nanotech 2010

Biologically Inspired Polymer Based Scaffold Development

M. Marimuthu, K. Kandasamy, S. Kim
Kyungwon University, KR

Keywords: PLGA, glucosamine, scaffold, microparticles, microfluidics


By utilizing polymeric biomaterials integrated microfluidic technology, we have developed a novel porous microfiber scaffold embedded with biologically inspired poly(D,L- lactic-co-glycolic acid)-Glucosamine (PLGA-GlcN) microparticles to minimize post implant inflammatory effect spontaneously and to produce controlled protein release simultaneously. A new anti-inflammatory drug (PLGA-GlcN) has been developed based on naturally occurring GlcN, an amino monosaccharide which is evinced as natural COX-2 inhibitor. A novel method of chemical grafting of the PLGA with GlcN was prepared using EDC system and their microparticles were made using simple W/O/W double emulsion technique. Amphiphilic triblock copolymer, poly(p-dioxanone-co- caprolactone)–block–poly(ethylene oxide)-block-poly(p-dioxanone-co-caprolactone) (PPDO-co-PCL-b-PEG-b-PPDO-co- PCL) microfibers loaded with microparticles with adhesive protein, fibronectin, were fabricated using a microfluidic device. Controlled fibronectin release and good cytocompatability of the microparticles embedded microfiber scaffold were observed. These results confirm that the microparticles loaded microfibers could be potentially used as an anti-inflammatory drug candidate for drug delivery and tissue regeneration applications.
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