Nanotech 2010

Inhibition of recurrence of Craniopharyngiomas by the controlled release of imatinib from PLGA microspheres

O. Karal Yilmaz, M. Kukut, E. Akgun, K. Baysal, T. Kilic
TUBITAK Marmara Research Centre, TR

Keywords: microspheres, PLGA, drug delivery, Craniopharyngioma

Abstract:

Craniopharyngiomas are histologically benign epithelial neoplasms of the suprasellar region that often exhibit aggressive and invasive growth . Although they may be totally excised by operation, recurrence of tumor is an important property of craniopharyngiomas. The biological behavior of these tumors are directly related to vascularization. It was thought that tumor proliferation, spread and recurrence are dependent on angiogenesis. Experiments have been performed to verify our hypothesis that the recurrence of craniopharyngiomas, which have a cystic component and show high PDGF activity, is in direct relation with angiogenic activity of these tumors. So, angiogenic activities of tumor samples has been investigated by immunohistochemistry staining. For each tumor sample, angiogenic potentials have correlated retrospectively with recurrence in the patient from which it was derived. So it has been seen that recurrent tumors show higher angiogenic activities than non-recurrent tumors. PLGA microspheres containing imatinib agent were synthesized using a modified double emulsion-solvent evaporation method. The microspheres were characterized by their morphology (SEM analysis) (Figure 1), size distribution (dynamic laser light scattering spectrometry), entrapment efficiency and release studies (HPLC). The inhibitory effects of imatinib on craniopharyngiomas was investigated on animals by “Rat Corneal Angiogenesis Model”.
 
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