Nanotech 2010

Delivery System for ZnPcSO4 based on Liquid Crystalline Phases for use in PDT of skin cancer

W.S.G. Medina, F.S.G. Praça, M.V.B.L. Bentley
University Of São Paulo, BR

Keywords: nanoparticule, liquid crystalline phase, delivery system, ZnPcSO4


Photodynamic therapy is a non-surgical minimally invasive approach, which has been used in the treatment of superficial epithelial tumors such as oral squamous carcinomas and skin cancer. In this study was developed a new nanodispersion system based on association of biodegradable surfactants with monoleine and aquos fase. That was characterized under a polarized light microscope before and after the sonication process used to disperse the hexagonal phase gel. The mean diameter and particle size distribution of the dispersion containing Zinc Phtalocyanine Tetrasulphonet were determined using a dynamic light scattering system. Particle size results showed that all samples were in the nanometric range associated with the ideal size distribution. Polydispersive index was lower than 0.21 indicating an appropriate monodisperse profile for distribution. The average diameter loaded was in the range of 140 and 200 nm approximately. Zeta potential surface was average value of -23,8 mV. And the turbidimetry was measure for 174 hours, and demonstrated stable. We concludes that the method for preparation of nanodispersion was accomplished with successful. The turbidimetry and lightscattering measurements revealed an stable, appropriate size and zeta distribution for long period.
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