Nanotech 2010

Novel mesoporous silicon particles as an efficient sustained delivery system for antibiotics

I. Yazdi, C. Chiappini, B. Weiner, M. Ferrari, E. Tasciotti
The University of Texas Health Science Center at Houston, US

Keywords: silicon, mesoporous, antibiotic, drug delivery, drug loading, surface chemistry

Abstract:

Delivery systems able to release antibiotics over an extended period of time can solve all these issues and provide efficacious alternative solutions to the current approaches. The ultimate objective of this study is to prove that MesoPorous Silicon (MPS) can be effectively used in combination with orthopedic implants and with scaffolds for bone tissue engineering to reduce the onset of infections and to enhance the ability of bone to heal in a timely fashion. MPS offers significant advantageous properties for drug delivery applications as it favorably extend drug pharmacokinetics, stability as well as bio-absorbability. We recently developed a multistage delivery system based on biodegradable MPS with well-controlled shapes, sizes and pores. The size of the pores confines the space for the entrapment of the antibiotic of choice while MPS surface chemistry affects the stability and duration of its interaction with the antibiotic and the surface chemistry can be easily altered and controlled to tune release kinetics. The ability to load drugs within the porous matrix of the particle at room temperature enabled the use of MPS also with sensitive compounds susceptible to temperature dependent degradation/inactivation. Moreover, we successfully integrated MPS in polymeric matrices to form composite materials for orthopedic applications.
 
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