Nanotech 2010

Multifunctional Fe3O4/ZnO core-shell nanoparticles for photodynamic therapy

J.C. Beltran, M.S. Tomar, S.P. Singh, O. Perales, L. Rivera, S. Peña
University of Puerto Rico, Mayaguez, PR

Keywords: core-shell, PDT, magnetic, Fe3O4/ZnO

Abstract:

The photodynamic therapy (PDT) based on core-shell structures require efficient luminescence within specific wavelength range, preferably in near infrared. In the present study we aim to create a multifunctional platform for PDT through Fe3O4/ZnO core shell structure. The magnetic properties of these nanostructures will enable us magnetically driven tumor targeting as well delivery of photosensitizer. On the other hand, ZnO is well known for reactive oxygen species (ROS) generation and will help to kill cancer cells through oxidative stress. Fe3O4/ZnO core-shell nanostructures are synthesized via a simple aqueous solution method and characterized using X-ray diffraction (XRD, Vibrating sample magnetometer (VSM), Electron Diffraction Spectroscopy (EDS), Photoluminescence (PL) measurements. The results on capability of generating active singlet oxygen are in progress and will be presented.
 
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