Nanotech 2010

Functional lipid nanostructures fabricated by dip-pen nanolithography

S. Lenhert
Florida State University, US

Keywords: dip-pen nanolithography, lipid, cell adhesion, biophotonic sensor


Combining the advantages of the structural, chemical, and lyotropic properties of membrane lipids with the nanostructuring capabilities of dip-pen nanolithograpy (DPN), makes possible creation of semisynthetic functional lipid nanostructures. Two examples of critical dimensions that are important to consider in determining size-dependent functions are: 1. The size of an individual cell (~1–100 micrometers) 2. The wavelength of visible light (~380–750 nanometers) The ability for phospholipid-based DPN to pattern biofunctional lipids across these scales opens the possibility of using subcellular patterns for biological studies of cell adhesion, as well as biophotonic structures for label-free investigation of liposome function and biosensing.
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