Nanotech 2010

Development of new thermo-ablation therapy using magnetic nanoparticles and device for alternating magnetic field

S. Hashimoto, T. Oda, K. Yamada, Y. Ohara, N. Ohkohchi, T. Kanamori, Y. Ikehata, I. Nagano, H. Yanagihara, M. Kishimoto, E. Kita
University of Tsukuba, JP

Keywords: hyperthermia, magnetic nano-particle, alternating magnetic field

Abstract:

Although induction heating cancer therapy (IHCT) using magnetic nanoparticles can be a promising approach to treatment-less multi-nodular cancers, combination of conventional super paramagnetic particle (SPIO) and standard alternating magnetic field (AMF) generator confer insufficient heat power for cancer cell necrosis. Intending to increase heat power in IHCT, we assume that employment of new high-power ferromagnetic particle (not SPIO!!) and ameliorated AMF should be indispensable. We originally developed new ferromagnetic particle (FP), which was 18 nm sized cobalt-contained iron oxide particle, and coated with SiO2. The spec of our original AMF device was as follows; the frequency was set to 114 kHz, the magnetic field could control from 0 to 450 Oe. The heat generating capacity of new ferromagnetic particle (FP) was 15 times higher than that of conventional SPIO. And tumor shrinking effects in subcutaneous tumor of animal experiment, by using our new FP + AMF resulted in complete response of all cases. On the other hand, SPIO + AMF resulted in incomplete response as residual viable tumors were evident. We would like to emphasize that we have succeeded in development promising nano-particles with high heating power, conferring dramatically total heating power sufficient for induction heating cancer ablation therapy.
 
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