Rapid and Ultra High Sensitive In Vitro Diagnostics (IVD) and POCT using Microfluidics and Lab-on-a-Chips

C. Ahn
University of Cincinnati, US

Keywords: MEMS, BIOMEMS, LOC, lab-on-a-chip

Summary:

The surface area to volume ratio of the microfluidic channel or chamber on lab-on-a-chip (LOC) shows a huge increase when compared to the well of a conventional 96-well immunoassay plate. The large surface area to volume ratio increases binding kinetics dramatically and allow rapid reactions. So, immunoassay reactions in the microchannel are inherently more efficient due to the large surface area to volume ratio and the short diffusion distances. In addition, owing to the fast reaction kinetics at micro scale, the microfluidic reaction can be used for a point-of-care testing (POCT) which usually requires a rapid analysis. So, the combination of lab-on-a-chips and microfluidics is attractive for the POCT diagnostics which has desires for rapid response, high sensitivity and small sample volume. Microfluidics is a new game changer for rapid and ultra-high sensitive immunoassays and in vitro diagnostic (IVD). In this talk, the distinctive natures of microfluidics on lab-on-a-chips are discussed first and then its applications to immunoassays, clinical diagnostics, IVD or POCT are presented.