Top Down Nanotechnology for Cancer Diagnostics

R. Bashir
University of Illinois, US

Keywords: cancer, nanotechnology

Summary:

Micro and nanotechnology can have many applications in cancer diagnostics and therapeutics. In this talk, we will present our work on use of top-down fabricated nanosensors for detection of biomolecules that are important for cancer. We will discuss two applications; (i) use of silicon nanowires on SOI wafers with high K dielectrics as the gate dielectrics for detection of biomolecules such as miRNA, and (ii) single molecule detection of DNA methylation using binding of MBD (methyl binding domain) proteins on DNA strands and then translocation of the complex through solid state nanopores.