Microtech 2011

Synthesis of Fine Pharmaceutical Particles by a Gaseous Antisolvent Mechanism

Y. Bakhbakhi, S.M. Alfadul, A. chafidz, A. Ajbar
King Saud University, SA

Keywords: pharmaceutical compounds, antisolvent, supercritical fluid, fine particles


Nonconventional processing techniques can lead to the development of materials with unique chemical, physical or mechanical characteristics that make them suitable for specialized applications. One such technique is synthesizing with supercritical fluids, where the unique fluid characteristics and solvent properties of supercritical fluids are utilized. In this work, Compressed Antisolvent (PCA) method has been employed to produce fine particles of some pharmaceuticals. Crystal particles with different morphology have been obtained at all successful PCA conditions. However, particles generally tend to coalesce in fine aggregate-gathering assemblage. The effect of the PCA process parameters on morphology, particle size and particle size distribution have been investigated. The ongoing study highlights the potential of PCA as a gaseous antisolvent based process as an attractive and scalable technology for the manufacturing of ultrafine particles for pharmaceutical applications.

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