Microtech 2011

Liquid-Phase Hydrogenation on Palladium-Coated Silica Nanospringsā„¢ in a Continuous Flow Reactor

O.G. Marin-Flores, T. Cantrell, T. Prakash, S. Ha, M. Grant Norton, D.N. McIlroy, G. Corti
GoNano Technologies, Inc., US

Keywords: nanosprings, continuos flow reactors


Catalytic hydrogenation processes in the liquid phase present challenges and difficulties due to the three-phase system formed by the solution, the solid-state catalyst and the gaseous hydrogen. Design of reliable experiments and analysis of the experimental data are the main points to be considered in these reactions. A continuous flow reactor (CFR) containing a film of immobilized palladium nanoparticles simplifies the study of the kinetics of liquid-phase hydrogenation processes. In addition, a CFR eliminates the post-processing work required to separate the catalyst particles from the reaction products. Palladium was selected for these hydrogenation processes because of its unique chemistry with hydrogen. In the present paper, we report the results obtained in a CFR using palladium nanoparticles supported on a silica Nanospring substrate for the reduction of 4-nitrophenol with sodium borohydride and hydrogen gas. Initial results shows that palladium supported on silica Nanosprings is a highly active catalytic material for continuous liquid-phase hydrogenation and represents a flow reactor solution to a key process in the pharmaceutical industry.

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