Microtech 2011

Vitamin E-assisted Superparamagnetic Iron Oxide Clusters Formation for Magnetic Resonance Imaging

J-R Lai, H-C Yen, C-Y Hsu, P-S Lai
National Chung Hsing University, TW

Keywords: MRI, iron oxide, clusters, vitamin E TPGS


Magnetic Resonance Imaging (MRI) has been regard as a noninvasive powerful imaging tool that yields excellent soft-tissue contrast, has a high spatial resolution, and possesses tomographic capabilities. Among the contrast agents used for MRI, superparamagnetic iron oxides (SPIO) serve as MRI T2-shortening agents for non-invasive cell or tissue imaging in clinic. In this study, we prepared clustered SPIOs with a diameter around 110 nm using vitamin E TPGS as a surfactant observed by DLS and TEM, leading to a significant advantage in terms of T2 relaxation and dose-dependent darkening of MR images compared with a commercial SPIO contrast agent (Resovist®). The better contrast enhancement using SPIO cluster may due to the collective properties of SPIO that are more responsive to an external magnetic field that thus can potentially act as efficient T2-shortening MRI contrast agents.

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