Microtech 2011

The Physics of Pressure Powered Micro-Flow Focusing Device for the Encapsulation of Live Cells

J. Berthier, P. Dalle, F. Rivera, R. Renaudot, S. Morales, P-Y. Benhamou, P. Caillat
CEA-Leti, FR

Keywords: encapsulation, live cells, FFD, flow regime

Abstract:

Flow focusing devices (FFD) have emerged as a powerful tool for cell encapsulation and formation of micro-emulsions [1,2]. In the frame of live cell encapsulation, a micro-FFD using alginate solutions for the capsule and powered by highly controllable pressure pumps has been developed [3,4]. This work deals with the different aspects of the problem: the rheology of alginates, the flow regimes and flow charts, the influence of the different parameters and a scaling analysis. Experimental observations of capsules produced in the microsystem are finally shown.
 

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