Microtech 2011

Topical Sensory Nanoparticles for in vivo Biomarker Detection

J. Patrone, J. Benkoski, M. Patchan, X. Calderon-Colon, H. Le, J. Sample

Keywords: nanoparticle, sensor, peroxide, disease


We have recently developed a non-toxic, topically applied biosensor using solid lipid nanoparticles (SLN). This diagnostic platform is currently designed to continuously monitor hydrogen peroxide levels in skin. Overproduction of hydrogen peroxide is implicated in the development of many diseases, and may indicate early infection as well as exposure to toxins or radiation. We have characterized the efficacy and toxicity of these particles using several in vitro models. We envision further developing our SLNs as a platform for pain-free, topical diagnostics, tailored to the detection of specific biomarkers found in skin, including hormones, DNA, cytokines, and cholesterol. SLN detection may also be expanded to include detection of arbitrary biomolecules using a double antibody sandwich assay, analogous to the ELISA assay.

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