Microtech2010 2010

Nanopore/electrode structures for single molecule biosensing

T. Albrecht
Imperial College London, UK

Keywords: solid-state nanopores, biosensing, DNA analysis, sequencing


In this contibution I will present some of our work on solid-state nanopores, the fabrication of nanopore/electrode structures and how these can be used for single-molecule biosensing applications (DNA, proteins etc.). Specifically, I will introduce a new way of fabricating small metal nanopores with diameters below 20 nm and well-defined pore conductance, based on electrodeposition and ion-current feedback control. This fabrication method is relatively inexpensive and can easily be multiplexed. Moreover, the surface properties of these metal nanopores can either be switched electrically (by applying a potential) or chemically by molecular self-assembly. Proof-of-concept single-DNA translocation experiments have been performed to show the applicability of the technique to fabricating single-biomolecule sensing devices. Finally, I will present some of our other work in this area on multi-electrode/nanopore devices.
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