Microtech2010 2010

Innovative Nanoprobes for Multiparametric Magnetic Immunoassays: Elaboration and Characterization

C. de Beaucorps, E. Alphandéry, F. Benyettou, A. Brioude, D. Bonnin, P. Weinmann, L. Motte, Y. Lalatonne
Avicenne Hôspital, FR

Keywords: magnetic immunoassays, multiparametric immunoassays, nanoparticles, nanoprobe, magnetosomes

Abstract:

Magnetic nanoparticles (MNPs) are commonly used for contrast enhancement in magnetic resonance imaging, as magnetic carriers in automated immunoassays instruments, or for cell concentration at the bench. They are being evaluated all over the world for drug delivery or cancer therapy by hyperthermia. More recently have MNPs been arisen as candidates for new labels in magnetic immunoassays in lieu of commonly used enzymatic, fluorescent, or radio-isotopic labels. The advantages of magnetic immunoassay are its great sensibility, its rapidity and its easy way of use. This study allows linking the MNPs physico-chemical properties with their magnetic behaviour and to build up a magnetic “signatures” library as to target the promising candidates for the MIAplex® technology. Those new MNPs will be extended to different biological models, leading to multiparametric testing.
 
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