Microtech2010 2010

Size-controlled synthesis of nanoparticles by seed-mediated process for medical application

T.D. Nguyen, D-J Kim, K-S Kim
Kangwon National University, KR

Keywords: size-controlled synthesis, particle growth, seed particles, gold nanoparticles, iron oxide nanoparticles


In recent years, a number of researches have focused on synthesis and application of nanoparticles because of their specific chemical and physical properties. These size-dependent properties are believed to be a result of the high ratio surface to bulk atom as well as the bridging state between atomic and bulk material. In order to fully understand size-dependent properties of nanoparticles, there are many methods developed to prepare monodisperse nanoparticles with different size and narrow size distribution. Seed-mediated process is considered as an ideal method to prepare nanoparticles with desired size. In the seed-mediated process, the small particles are generated and then they are used as the seed particles for the subsequent growth by exposing them to a mild condition of extra precursor with reducing/participating agents. In principle, for the synthesis of monodisperse nanoparticles with desired size by seed-mediated growth, the experimental condition should be decided on that all new precursor are consumed and condensed on the surface of seed particles without new nucleation. In this study, we prepared gold and magnetite iron oxide nanoparticles by the seed-mediated process to analyze the growth and nucleation systematically. The amount of precursor added to the seed colloidal solution was varied to investigate its effects on the growth of nanoparticles. From 16.8 nm gold seed particles, the gold nanoparticles ranging from 32.2 nm to 48.1 nm were prepared with monodisperse size distribution by citrate reduction reaction for various amounts of added HAuCl4. For iron oxide nanoparticles, single domain Fe3O4 nanoparticles were prepared with the saturation magnetization of ~ 83 emu/g by precipitation of Fe2+/Fe3+ with NH4OH. Fe3O4 nanoparticles in the sizes of 16 nm and 20 nm were successfully synthesized from 10 nm seed particles by seed-mediated process.
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