Materials for Drug & Gene Delivery

Symposium Chair

Steven Zullo
NIBIB/NIH

Confirmed Invited Speakers

	The Art of Falling Apart: On-demand Release from Polymeric Carriers Adah Almutairi Professor, Laboratory for Bioresponsive Materials, University of California, San Diego
	Promises and challenges in the translation of image-guided cancer therapy using theranostic nanoparticles Lily Yang Professor of Surgery, Winship Cancer Institute, Emory University School of Medicine
	Opportunities and Challenges for Personalized Cancer Therapy Using Biotargeted Nanomedicines Fatih Uckun Professor, USC Norris Comprehensive Cancer Center; CHLA Children’s Center for Cancer & Blood Diseases, Univ. of Southern California

	Overcoming Delivery Obstacles with Cholesterol Nanodomains Tom Anchordoquy Professor, Department of Pharmaceutical Sciences, University of Colorado School of Pharmacy
	Induction of Tolerance for Therapy of Autoimmune Diseases Using Antigen-Linked Biodegradable PLG Nanoparticles – Mechanisms and Stephen Miller Judy E. Gugenheim Professor of Microbiology-Immunology, Northwestern University Medical School
	Nanosponge Delivery Systems: Superior targeted delivery through nanosolubilization, tailored release profiles and practical synthesis Eva Harth Associate Professor, Vanderbilt University

Scaleable Polymeric Nanoparticle Formation for Multifunctional Drug Delivery and Imaging
Robert K. Prud’homme
Professor of Chemical and Biological Engineering, Director, Program in Engineering Biology, Princeton University

Immunotherapy with nanoparticles targeting ion channels: research and application challenges
Laura Conforti
Associate Professor, Pathobiology and Molecular Medicine, University of Cincinnati

Symposium Sessions
	Tuesday May 14
11:00	Materials for Drug & Gene Delivery I
	Materials for Drug & Gene Delivery - Posters 1:30
3:30	Materials for Drug & Gene Delivery II
4:30	Innovation Spotlights: Pharma & Medical Devices
	Wednesday May 15
10:30	Materials for Drug & Gene Delivery III
11:00	Innovation Spotlights: Pharma & Biotech
2:00	Polymers for Drug and Gene Delivery
4:00	Innovation Spotlights: Medical Devices
	Materials for Drug & Gene Delivery - Posters 5:00

Symposium Program
	Tuesday May 14
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11:00	Materials for Drug & Gene Delivery I	Chesapeake 4-5
	Session chair: Steven Zullo, NIBIB/NIH, US
11:00	Materials for Drug & Gene Delivery: Veracity of Our Crystal Ball (invited presentation) S. Zullo, NIBIB, US (bio)
11:10	Nanosponge Delivery Systems: Superior targeted delivery through nanosolubilization, tailored release profiles and practical synthesis (invited presentation) E. Harth, Vanderbilt University, US (bio)
11:35	Promises and challenges in the translation of image-guided cancer therapy using theranostic nanoparticles (invited presentation) L. Yang, W. Qian, M. Satpathy, L. Wang, G.Y. Lee, Z. Cao, R. Zielinski, J. Capala, S. Nie, Y.A. Wang, H. Mao, Emory University School of Medicine, US (bio)
12:00	Scaleable Polymeric Nanoparticle Formation for Multifunctional Drug Delivery & Imaging (invited presentation) R.K. Prud’homme, Princeton University, US
12:25	Opportunities and Challenges for Personalized Cancer Therapy Using Biotargeted Nanomedicines (invited presentation) F. Uckun, University of Southern California, US (bio)
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	Materials for Drug & Gene Delivery - Posters 1:30	Expo Hall A
-	Cerium oxide nanoparticles alleviate experimental autoimmune encephalomyelitis in mice J.S. Erlichman, M.L. Brackett, Cerion NRx LLC, US
-	Targeted delivery of siRNAs against ion channels by lipid nanoparticles in T cell subsets P. Hajdu, University of Cincinnati, US
-	Novel Photo-thermal Controlled Drug-releasing Vectors for Cancer Detection and Treatment M-H Tsai, D. Ling, M-J Shieh, National Taiwan University, TW
-	Study on the polymeric nanosphere with imaging functionality M-H Lin, T-Y Liu, Institute of Biomedical Engineering, National Yang-Ming University, Taipei, 112 Taiwan (ROC), TW
-	Study of protoporphyrin IX-loaded silica hollow spheres for Photodynamic therapy G-H Tseng, T-Y Liu, National Yang-Ming University of Taiwan, TW
-	Nanovesicle‐Bioactive Conjugates Prepared by a One‐Step Scalable Method N. Ventosa, I. Cabrera, E. Elizondo, O. Esteban, J.L. Corchero, M. Melgarejo, D. Pulido, A. Córdoba, E. Moreno, U. Unzueta, CSIC, ES
-	Effect of cholesterol on the transfection efficiency of DOTAP-containing lipoplexes D. Pozzi, F. Cardarelli, F. Salomone, C. Marchini, H. Amenitsch, G. Caracciolo, Sapienza University of Rome, IT
-	Tailored, Linear Release with Modular Nanosponge Delivery Systems E. Harth, D. Stevens, G. Li, Vanderbilt University, US
-	Strategy to produce low molecular weight chitosan nanoparticles for gene/vaccine therapy with controllable polidispersity C.C. Sipoli, N. Santana, L.G. de La Torre, State University of Campinas (UNICAMP), BR
-	Approaches to surface-functionalised materials for biomedical applications D.W. Pitt, A. Treharne, M.C. Grossel, University of Southampton, UK
-	Reduction-sensitive hyaluronic acid nanoparticles for targeted intracellular deliery of doxorubicin G. Saravanakumar, J.M. Shin, W. Um, J.H. Park, Sungkyunkwan University, KR
-	Thermosensitive Vaginal Gel Containing PLGA-NTRI Conjugate Nanoparticles for HIV Prophylaxis A. Rajca, Q. Li, A. Date, C. Destache, Creighton University School of Pharmacy & Health Professions, US
-	Colloidal Structures of Micro-and Nano- Drug Particles in Polymeric Networks P. Takhistov, P. Huynh, Rutgers, the State University of New Jersey, US
-	Development of Drug Delivery System Using Bio based Calcium carbonate Nanoparticles D. Render, V. Rangari, T. Samuel, J. Ramapuram, K. Pawar and S. Jeelani, Tuskegee University, US
-	Endothelial cell derived exosome nanoparticle to deliver siRNA A. Banizs, T. Huang, J.S. Lee, W. Shi and J. He, University of Virginia, US
-	The potential applications of SOS-lux biosensors for rapid screening of mutagenic chemicals H.A. Alhadrami, G.I. Paton, University of Dammam, KSA, & University of Aberdeen, UK, SA
-	Microfluidic Impedance-Metric Biosensor for Monitoring Carbon Nanotube-Induced Epithelial Permeability Z. Huang, N. Wu, Y. Rojanasakul, Y. Liu, West Virginia University, US
-	A sensitive protein detection based on fluorescent dye-doped silica nanoparticles and lateral flow test strip S. Bamrungsap,C. Apiwat, T. Dharakul and N. Wiriyachaiporn, NANOTEC Thailand, TH
-	Key parameters to control the design of CycloRGD multimodal Imaging contrast agent J. Bolley, O. Haddad, E. Guenin, Y. Lalatonne, L. Motte, Paris 13 University, FR
-	Superparamagnetic Nanoparticles for Immuno Imaging of Brain Tumors by IRM S. Richard, A. Herbet, Y. Lalatonne, S. Mériaux, F. Ducongé, J-P. Hugnot, E. Guénin, D. Boquet, L. Motte, Université Paris 13 - UFR SMBH, FR
-	Discovery and characterization of the sensing modalities of novel diamond-graphene hetero-structures M. Bockrath, I. Kierk, California Institute of Technology, US
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3:30	Materials for Drug & Gene Delivery II	Chesapeake 4-5
	Session chair: Steven Zullo, NIBIB/NIH, US
3:30	The Art of Falling Apart: On-demand Release from Polymeric Carriers (invited presentation) C. de Gracia Lux, M.L. Viger, N. Fomina, J.E. Olejniczak, A. Almutairi, University of Californi, San Diego, US (bio)
3:50	Overcoming Delivery Obstacles with Cholesterol Nanodomains (invited presentation) T. Anchordoquy, University of Colorado Denver, US (bio)
4:10	Induction of Tolerance for Therapy of Autoimmune Diseases Using Antigen-Linked Biodegradable PLG Nanoparticles – Mechanisms and Clinical Prospects S. Miller, D. Getts, A. Martin, D. McCarthy, R. Terry, Z. Hunter, W. Yap, M. Getts, M. Pleiss, X. Luo, N. King, L. Shea, Northwestern University Medical School, US (bio)
4:30	Deploying RNA and DNA using a functionalized carbon nanotube platform: implications for gene delivery S. Alidori, K. Asqiriba, P. Londero, M. Bergkvist, M. Leona, D.A. Scheinberg, M.R. McDevitt, Memorial Sloan-Kettering Cancer Center, US
4:50	Nanosystem for targeting Treg in vivo M. Bottini, C. Sacchetti, N. Rapini, N. Rosato, A. Magrini, N. Bottini, Sanford Burnham Medical Research Institute, US
5:10	Multifunctional squalenoyl nanocomposites for pancreatic cancer: diagnostic and therapeutic aspects S. Valetti, B. Stella, S. Mura, D. Desmaële, F. Maione, E. Giraudo, L. Cattel, P. Couvreur, University of Paris, FR
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4:30	Innovation Spotlights: Pharma & Medical Devices	Potomac 2
	Session chair: Lynn Foster, BPT Pharma, US
4:30	Language Analysis Tool Detects Cognitive Dysfunction for Early Alzheimer Diagnosis A. Morrow, University of Minnesota, US
4:37	Treating type 2 diabetes using menin inhibitors to regenerate insulin producing beta cells F. Leu, Novapeutics LLC, US
4:44	Integrated Continuous Manufacturing (ICM) of Pharmaceuticals S. Mascia, CONTINUUS Pharmaceuticals, US
4:51	Highly Sensitive Micron Scale Multiple Biomarker Biosensor C. Yilmaz, Biolom, LLC, US
4:58	Personal Health Expert V. Shusterman, PinMed, US
5:05	Flex Technology Inc W. Krause, Flex Technology Inc, US
5:12	Pharmaceutical technology of pharmaceutical composition and pharmacology treatment for enhancement of morphine analgesia and prevention of morphine tolerance C. Laino, Biotechnology Institute, National University of La Rioja, AR
5:19	Modular Biocompatible Materials for Medical Devices and Wound Healing Applications S. Foster, Diazamed-CSU Ventures, US
	Wednesday May 15
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10:30	Materials for Drug & Gene Delivery III	Chesapeake 1-3
	Session chair: Steven Zullo, NIBIB/NIH, US
10:30	Immunotherapy with nanoparticles targeting ion channels: research andapplication challenges (invited presentation) L. Conforti, University of Cincinnati, US (bio)
10:55	Programming and switching the pharmacokinetics of nanoscale delivery vehicles in vivo M.-P. Chien, N.C. Gianneschi, University of California, San Diego, US
11:15	Magnetic Field-Induced Cyclizations of Amino-Esters and -Carbonates Bound to Iron Oxide Nanoparticles R.J. Knipp, O. Uradu, M.H. Nantz, University of Louisville, US
11:35	Gold-Coated Liposomes Encapsulating Signaling Molecules for Initiating Cellular Communication G.V. Orsinger, M. Romanowski, University of Arizona, US
11:55	Magnetically driven drug release from Fe3O4-phage network C.B. Mao, University of Oklahoma, US
12:15	NanoBandage for Controlled Release of Topical Therapeutics M. Patchan, X. Calderon-Colon, J. Benkoski, M. Theodore, H. Le, B. Fuller, N. Boggs, A. Nelson, L. Garza, K. Sarkar, G. Brandacher, J. Patrone, The Johns Hopkins University Applied Physics Laboratory, US
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11:00	Innovation Spotlights: Pharma & Biotech	Potomac 3
	Session chair: Belen Martinez-Lopez, CaramelTech, MX, Reviewers: Roche, Sanofi, Merck, Jennifer Gottwald, WARF, US
11:00	Roche - Strategic Innovation Interests M. Wetzel, Roche, US
11:15	Sanofi - Strategic Innovation Interests S. Natesan, Sanofi, US (bio)
11:30	Merck - Strategic Innovation Interests S. Xanthoudakis, Merck, US (bio)
12:00	Targeted Drug Delivery System/Keystone Nano D. Fecko, Penn State Materials Research Institute, US
12:07	Novel SiO2-based antioxidant compound with significantly extended life-time and activity G. Sotiriou, ETH Zurich – ETH transfer (the Technology Transfer Office), CH
12:14	Diabetes Control Algorithms and Clinical Trial Software S. Juncal, UCSB Office of Technology & Industry Alliances, US
12:21	Biodegradable Polymer for Biomedical Applications L. Besemann, University of Minnesota, US
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2:00	Polymers for Drug and Gene Delivery	Chesapeake 1-3
	Session chair: YuanQiao Rao, Dow Chemical Company, US
2:00	Non-ionic Dendronized Multiamphiphilic Polymers as Nanocarriers for Biomedical Applications S. Gupta, B. Schade, S. Kumar, C. Böttcher, R. Haag, S.K. Sharma, University of Delhi, IN
2:20	New biodegradable polymers based on previously unknown functional groups for drug and gene delivery J. Yoo, T.A. Graf, D.J. Kuruvilla, S.R. D’Mello, A.K. Salem, N.B. Bowden, University of Iowa, US
2:40	Reverse Thermoresponsive Polymers for Sustained Delivery of Therapeutic Agents R. Mayadunne, A. Balachandra, T. Gunatillake, C. Lindall, CSIRO, AU
3:00	Exploiting the “protein corona effect” for targeted drug and gene delivery G. Caracciolo, D. Pozzi, A.L. Capriotti, C. Cavaliere, F. Cardarelli, F. Salomone, A. Laganà, Sapienza University of Rome, IT
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4:00	Innovation Spotlights: Medical Devices	Potomac 1
	Session chair: Allen Dines, University of Wisconsin-Madison, US
4:00	Fiberoptic Microneedle Device for Convection-Enhanced Thermochemotherapy of Malignant Glioma C. Rylander, Virginia Tech Intellectual Properties, Inc., US
4:07	CANCELED - Operation system of laparoscope using pneumatically driven robotic holder M. Yamamoto, Japan Technology Group Inc., JP
4:14	A high throughput one-step assay for circulating tumor cell detection in whole blood sample Y. Zu, The Methodist Hospital, US
4:21	CereScope™ - A Portable All-in-One Neurological Monitoring System R. Kern, Optima Neuroscience, Inc., US
4:28	Medipacs Mini-Infuser™ M. Banister, Medipacs.com, US
4:35	Flat Panel X-ray Sources M. Eaton, Stellarray, US
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	Materials for Drug & Gene Delivery - Posters 5:00	Maryland
-	Combinatorial Cationic Lipid-like Nanoparticles for Efficient Intracellular Cytotoxic Protein Delivery Q.B. Xu, M. Wang, Tufts University, US
-	Lipid nanoparticles for enhancing immune responses to protein antigens T. Courant, H.L. Reynaud, A. Hoang, C. Villiers, F. Mittler, I. Texier, P.N. Marche, F.P. Navarro, CEA LETI MINATEC, FR
-	Surface and Sefl-Associaciation Interaction of Proteins Characterized by QCM-D A. Jaiswal, M. Poggi, Biolin Scientific, Inc., US
-	Anchoring of self-assembled plasmid DNA/anti-DNA antibody /cationic lipid micelles on bisphosphonate-modified stent for cardiovascular gene delivery G.L. Ma, Y. Wang, I. Fishbein, M. Yu, L.H. Zhang, I.S. Alferiev, J. Yang, C.X. Song, R.J. Levy, Chinese Academy of Medical Sciences and Peking Union Medical College, CN
-	Fabrication of stable bio-compatible mesoporous silica and core-shell silica-magnetite nanoparticles for potential application in drug delivery M.E. Sharifabad, T. Mercer, T. Sen, University of Central Lancashire, UK
-	A New DNA-Based Carrier for Targeting and Intracellular Transport of Therapeutics S. Muro, University of Maryland College Park, US
-	Commercializing unique nanoparticle-imaging-delivery platform technology for enhanced cancer therapy A. Fu, NVIGEN, Inc., US
-	Cationic lipid nanoemulsions for RNAi screening J. Bruniaux, E. Sulpice, F. Mittler, I. Texier, X. Gidrol, F.P. Navarro, CEA LETI MINATEC, FR
-	Epidermal Growth Factor-Ferritin H-Chain Nanoparticles as Nanocarrier of Y. Huang, X. Chen, X. Cao, East China University of Science and Technology, CN
-	Lysozyme – alginate nanocomplex: Effect of alginate composition J.P. Fuenzalida, P.K. Nareddy, I. Moreno-Villoslada, B. Moerschbacher, M.J. Swamy, F.M.A. Goycoolea, Westfälische Wilhelms-Universität Münster, DE
-	Near-Infrared Mediated Photothermal Ablation of Cancer Cells using Low Band Gap Polymer Nanoparticles C.M. MacNeill, R.C. Coffin, D.L. Carroll, N.H. Levi-Polyachenko, Wake Forest University Health Sciences, US

Special Symposium

Biocompatible materials with nano-scale structure hold great promise as controlled release reservoirs for delivery of both small-molecule drugs and various classes of biomacromolecules, such as peptides, proteins, plasmid DNA and synthetic oligodeoxynucleotides. Promising delivery systems include microcapsules, liposomes, macromolecular conjugates, nanoparticles, dendrimers, and biological nanostuctures such benign viruses and bacteriophages. This symposium will focus on success stories and reports of exciting new nanostructured materials and approaches for drug and gene delivery.

Topics & Application Areas

Targeting at molecular, cellular & higher levels
Antibody targeting
Modes of entry
Controlled release systems
Microcapsules
Liposomes
Polymer-based delivery systems
Protein/peptide delivery
Pharmacodynamics
Novel delivery systems
Nanomedicine clinical trials: challenges & results
Other

Technical Abstract Submission

Please first review the information for authors as well as the abstract preparation guidelines.

Journal Submissions

Nanomedicine: Nanotechnology, Biology and Medicine (Nanomedicine)

Nanomedicine NBM publishes articles on all issues related to nanomedicine, including the application of nanoscience and nanotechnology in biology and medicine.

Manuscripts must be directly or closely related to medicine (diagnosis, treatment, monitoring, prognosis and prevention of diseases) and supporting biology, especially understanding biologic mechanisms enabled by nanoscience, -engineering and -technology research, i.e.such as, research of man-made nanoscale objects, materials, and devices that improve medical procedures and outcome.

For consideration into the Nanomedicine: Nanotechnology, Biology and Medicine journal please select the “Submit to Nanomedicine: Nanotechnology, Biology and Medicine” button during the on-line submission procedure.

Journal of Nanoparticle Research

Selected Nanotech Proceedings papers will be reviewed and invited into a Special Issue of Journal of Nanoparticle Research. The journal disseminates knowledge of the physical, chemical and biological phenomena and processes in nanoscale structures.

For consideration into this Special Issue of Journal of Nanoparticle Research, please select the “Submit to Journal of Nanoparticle Research” button during the on-line submission procedure.