Nanomechanics of intrinsically disordered proteins: interplay of force, form and function

Kuan Wang

Kuan Wang

Director of the Nanomedicine Program

Academia Sinica

Taiwan

Dr. Kuan Wang is currently the Director of Nanomedicine Program and distinguished research fellow at the Institute of Biological Chemistry and Institute of Physics, at Academia Sinica, Taiwan.

Dr. Wang’s research has made significant contributions to the study of muscle biology and cell motility, including the discovery and naming of five new cytoskeletal proteins (filamin, titin, nebulin, P235 (talin) and nebulette) important in assembly, regulation and dysfunction of the cytomatrix in cardiac, skeletal and smooth muscles and in non-muscle cells. Three drug-discovery projects are under development: the rational design of drug toward intrinsically disordered, elastic protein domains in signaling proteins; the application of micro-patterned skeletal and cardiac cells on elastic substrates as cell-based platforms for drug discovery, and nano-patterned motile proteins on fabricated device as molecule-based platforms for drug discovery, and the application of Fast System Control technique to development combinatorial drugs for cardiovascular, cancer and infectious diseases.

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