Biomimetic Biphasic Nanocomposite Scaffold for Osteochondral Regeneration

N.J. Castro, C. O’Brien, L.G. Zhang
The George Washington University, US

Keywords: growth factors, nanospheres, scaffold, osteochondral, interface

Summary:

The current work focused on the development and evaluation of a novel biomimetic biphasic nanocomposite scaffold for osteochondral interfacial tissue engineering. Tissue-specific growth factor-encapsulated nanospheres were manufactured via a wet electrospray technique and incorporated within the respective layer of our biphasic model. Human bone marrow derived mesenchymal stem cells were seeded, cultured, and evaluated. Two-week differentiation results illustrated increased collagen and calcium deposition on nanosphere containing scaffolds when compared to other test samples.