NAD-Nanoparticles for Therapy and Diagnosis of Alzheimer Disease

M. Masserini, M. Gregori, E. Salvati, F. Re, M. Masserini
University Milano Bicocca, IT

Keywords: Alzheimer disease, blood brain barrier, nanoparticles

Summary:

NAD project (large cooperative; 19 partners, funded by the E.C.) is aiming to the therapy and diagnosis, even combined, of Alzheimer Disease, by synthesis of multiple-functionalized nanoparticles, able to bind, detect and remove Abeta from the brain and from the blood. NAD partners have realized different types of NPs (liposomes, SLN, PHDCA) specifically functionalized to bind Aβ with high affinity and to cross the blood brain barrier in vitro. Treatment of animal models of the disease (TG mice) suggest that double-functionalized NP can decrease the levels of Abeta in the blood and the content of Abeta in the brain. More than 40 papers have been published and 4 patents filed.