Lipid-based Phototriggerable Platforms for Improved Delivery of Anticancer Drugs

A. Puri
Frederick National Lab for Cancer Research, US

Keywords: cancer nanotechnology

Summary:

Light-based therapies aided by nanoparticles can be primarily categorized into two main platforms: (i) conventional nanoparticles for delivery of payload of photosensitizers, and (ii) phototriggerable nanoparticles for site-specific delivery of drugs and pharmaceuticals. Several strategies have been explored for optimal drug release from nanoparitcles within defined space and time (Triggered Release). Light-sensitive liposomes present a promising system and rely on strategically designed lipids to initiate phototriggering. The mechanism(s) of photo-triggering either include (a) fluorophore-mediated activation of lipids, or (b) direct intra/inter-lipid modifications1. The principle criterion for clinically viable formulations, however, entails design of lipid molecules responsive to tissue-penetrating wavelengths. We have developed phototriggerable liposomes that include a diacetylenic phospholipid, DC8,9PC (1,2 bis(tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine)2,3. I will present recent developments on these formulations. References: Yavlovich, Smith, Gupta, Blumenthal, Puri. Mol. Membr. Biol 27:364-81 (2010) Puri and Blumenthal. Acc. Chem. Res 44: 1071-9 (2011) Yavlovich, Singh, Blumenthal, Puri. Biochim. Biophys. Acta 1808:117-126 (2011)