A better biomaterial for bone regeneration: type II collagen

Y.H. Tsai
Taipei Medical University, TW

Keywords: type II collagen, hNSC, osteogenesis, calcium deposition, bone regeneration

Summary:

Type II collagen facilitates osteogenesis and suppresses adipogenesis simultaneously during early stage of MSC differentiation, mediated through the same signaling cascades. Type II collagen-coated plates enhanced BMSC mineralization better than did either non-coated or type I collagen-coated groups. While implanted in the fracture bone of rats, the type II collagen-HA/TCP (nano-particle) scaffold group showed significant faster bone formation at the reunion site, higher SFI scoring of foot-stepping and better locomotion as comparing to that of control group or type I collagen-HA/TCP group did. Collectively, type II collagen serves as an important modulator during early osteogenic differentiation of BMSCs, and enhance bone defect repair through an endochondral ossification-like process. The information advances our understanding about the cartilaginous ECM-BMSC interaction and provides perspective strategies for faster bone regeneration