Superparamagnetic Nanoparticles for Immuno Imaging of Brain Tumors by IRM

S. Richard, A. Herbet, Y. Lalatonne, S. Mériaux, F. Ducongé, J-P. Hugnot, E. Guénin, D. Boquet, L. Motte
Université Paris 13 - UFR SMBH, FR

Keywords: superparamagnetic nanoparticles, theranostic, imaging

Summary:

Gliomas are the most common primary brain tumour in humans, affecting around 25000 people each year in Europe. To date, the only treatment of care consists of surgical removal of the tumour bulk, irradiation and chemotherapy, with finally a very poor prognosis. Litterature and our personal works demonstrate that endothelin receptor B, EDNRB, is much more expressed in glioma stem cell cultures than in conventional glioma cell lines. EDNRB antagonists had already administrated to patients during clinical assays for glioma treatment. These results underline the significance to target EDNRB for imaging and/or eradicating glioma stem cells. Moreover, MNPs are excellent MRI contrast agents because of their transverse relaxation T2* property, as compared to other MRI agents. MNPs can be also used for drug delivery coating the nanoparticle surface with therapeutic molecules. Hence, this hybrid nanosystem combines both MR (diagnostic) and therapeutic applications. This strategy is referred to theranostic strategy.