The Development of Stealth Poly-Ɛ-Caprolactone Nanoparticles For the Delivery of Bioactive Agents

O. Ogunwuyi, E. Akala
Howard University, US

Keywords: nanoparticles, poly-Ɛ-caprolactone, in-situ polymerization

Summary:

Polyesters have gained a lot of prominence because of their use in drug delivery. They are the most widely used polymers in biomedical applications because they are biocompatible, non-immunogenic, non-toxic and are approved for use in vivo by the Food and Drug Administration (FDA). The polyesters include poly(lactic acid), poly glycolic acid, poly(lactide-co-glycolide), and poly-ε- caprolactone. Over the years, polyesters have been fabricated into nanoparticles using preformed polymers. In recent time, in-situ polymerization technique is being applied to the fabrication of nanoparticles. The technique has a lot advantages such as the opportunity to tether various materials to the nanoparticles and one step synthesis of the nanoparticles. In this study, stealth poly-ε-caprolactone nanoparticles have been fabricated by the in-situ polymerization method. However, prior to the use of the ε-caprolactone as a macromonomer, it was end-functionalized to give it a polymerizable end-group. The nanoparticles particles were analyzed by scanning electron microscopy and particle size determinations.