Radiation sculpured nanogels: a new platform for therapeutic nanodevices

C. Dispenza, N. Grimaldi, M.-A. Sabatino, G. Adamo, S. Rigogliuso, G. Ghersi
Università degli Studi di Palermo, IT

Keywords: nanogels, nanocarriers, active targeting


Nanogels (NGs), or small particles formed by physically or chemically crosslinked polymer networks, offer unique advantages in the development of “smart” nanoparticles for drug delivery and diagnostics. They have a large and flexible surface for multivalent bio-conjugation; an internal 3D aqueous environment for incorporation and protection of (bio)molecular drugs; the possibility to entrap molecules, metal or mineral nanoparticles for imaging or phototherapeutic purposes; stimuli- responsiveness to achieve temporal and/or site control of the release function and biocompatibility. The availability of inexpensive, robust and versatile synthetic methodologies is at the basis of the development of effective nanogel-based theragnostic devices. We have established that nanogels can be produced with high yields and through-puts by pulsed e-beam irradiation of dilute aqueous solutions of water-soluble biocompatible polymers and functional groups bearing monomers, e.g. poly(N-vinyl pyrrolidone) (PVP), acrylic acid (AA) or aminopropyl methacrylamide (APMAM), using industrial electron accelerators and set-ups