Radiation sculpured nanogels: a new platform for therapeutic nanodevices

C. Dispenza, N. Grimaldi, M.-A. Sabatino, G. Adamo, S. Rigogliuso, G. Ghersi
Università degli Studi di Palermo, IT

Keywords: nanogels, nanocarriers, active targeting

Summary:

Nanogels (NGs), or small particles formed by physically or chemically crosslinked polymer networks, offer unique advantages in the development of “smart” nanoparticles for drug delivery and diagnostics. They have a large and flexible surface for multivalent bio-conjugation; an internal 3D aqueous environment for incorporation and protection of (bio)molecular drugs; the possibility to entrap molecules, metal or mineral nanoparticles for imaging or phototherapeutic purposes; stimuli- responsiveness to achieve temporal and/or site control of the release function and biocompatibility. The availability of inexpensive, robust and versatile synthetic methodologies is at the basis of the development of effective nanogel-based theragnostic devices. We have established that nanogels can be produced with high yields and through-puts by pulsed e-beam irradiation of dilute aqueous solutions of water-soluble biocompatible polymers and functional groups bearing monomers, e.g. poly(N-vinyl pyrrolidone) (PVP), acrylic acid (AA) or aminopropyl methacrylamide (APMAM), using industrial electron accelerators and set-ups