Luminescent Water Soluble Carbon Quantum Dots for Bio-imaging and Target Drug Delivery

A. Allam, A. Allam
Cromoz Inc, US

Keywords: carbon quantum dots for bio-imaging


Biologists for years have been trying to visualize the movement and action of proteins and other molecules in and around cells and tissues. Transgenic way of attaching green fluorescence proteins started to help in such investigation. For wild species organic quantum dots (QDots) are being used. A blast of light makes these little specks glow different colors according to their size, allowing the masterpiece of life to become visible and color-coded. However, current QDots (like CdSe/ZnS) are far from ideal for biology and medicine because these are toxic to the cells. Researchers are beginning to look at carbon quantum dots for bio-imaging in medical field as they are bio-friendly and non toxic. Some researchers have produced fluorescent carbon quantum dots by functionalization the surfaces and by passivizing the surfaces by organic wrappers. Our research has produced fluorescent multi-walled carbon QDots by functionalization the surfaces and with no external passivation of surfaces with any organic wrappers. These carbon QDots are produced from organic resources and not from commonly used laser ablation techniques. We have successfully conjugated these water-soluble functionalized carbon QDots with Paclitaxel and Gemcitabine. Initial in vitro studies on certain cancer cell lines at Johns Hopkins have shown no cytotoxicity.