Curcumin-loaded monostearin lipid carriers: synthesis and characterization

Y. Du, P. Takhistov
Rutgers, the State University of New Jersey, US

Keywords: curcumin, nanoemulsion, solid lipid nanoparticles

Summary:

Curcumin belongs to the group of flavonoids. Recent research shows it possesses remarkable antioxidant and anti-inflammatory properties beneficial for human health. However, its bioavailability is greatly limited by its hydrophobic nature and rapid degradation in GI tract. Furthermore, it easily decomposes in the presence of light, limiting its use in foodstuff. Therefore, a protective carrier is needed to improve its stability, which would result in improved bioavailability and products shelflife. Lipids have traditionally been used as building blocks of such carriers due to their compatibility with polyphenols and ability to provide protective barrier for hydrophobic compounds. We report successful encapsulation of Curcumin into lipid nanoparticles. Our experimental data shows a great improvement in the stability of Curcumin in the aqueous phase. Solid lipid nanoparticles were made from stearic acid methyl ester and monostearin mixture. Additionally, oleic acid and Polyethylene glycol were used as plasticizers and crystallization inhibitors. Obtained particles were characterized with various analytical and imaging techniques - Dynamic Light Scattering and Transmission Electron Microscopy, and Raman Spectroscopy, to analyze particles size distribution and the morphology of lipid nanoparticles, and reveal the structure and possible interactions between Curcumin and the carrier matrix. The Curcumin encapsulation mechanism into lipid nanonparticles will be presented.